Trophoblasts reduce the vascular smooth muscle cell proatherogenic response

Hypertension
Lydia HeringRalf Dechend

Abstract

Maternal spiral artery remodeling is the consequence of controlled trophoblast invasive interaction with the maternal cellular environment and is fundamentally important for successful placentation. In preeclampsia, trophoblast invasion is shallow, remodeling is incomplete, and vessels develop an inflammatory appearance, termed "acute atherosis." We noted that, in our preeclampsia, human renin-human angiotensinogen transgenic rat model, complement component 3 (C3), and tumor necrosis factor-alpha were upregulated and heavily expressed in atherotic uteroplacental vessels. We next used coculture involving human trophoblasts, rat vascular smooth muscle cells (VSMCs), and human VSMCs to observe VSMC-trophoblast regulatory interactions. Tumor necrosis factor-alpha induced complement C3 and interleukin-6 expression in VSMCs. We found that trophoblasts were able to reduce VSMC C3 and interleukin-6 expression after the VSMCs were stimulated with tumor necrosis factor-alpha. However, a direct VSMC-trophoblast cell-cell contact was necessary for this anti-inflammatory response. We also studied double-transgenic VSMCs that express inflammatory components and exhibit accelerated proliferation ("synthetic" phenotype). Trophoblasts could not...Continue Reading

References

Aug 1, 1994·British Journal of Obstetrics and Gynaecology·J W MeekinsA van Asshe
May 30, 1998·Current Biology : CB·P TaylorM Walport
Feb 16, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R Pijnenborg
Oct 29, 2000·Journal of the American Society of Nephrology : JASN·Jürgen BohlenderFriedrich C Luft
Feb 24, 2001·Lancet·J M Roberts, D W Cooper
Apr 12, 2001·The New England Journal of Medicine·M J Walport
Apr 12, 2002·Placenta·J E CartwrightG St J Whitley
Mar 8, 2003·Hypertension·James M RobertsUNKNOWN NHLBI Working Group on Research on Hypertension During Pregnancy
Mar 19, 2004·Biology of Reproduction·S CampbellE D M Gallery
Jul 17, 2004·Acta Obstetricia Et Gynecologica Scandinavica·Nina Kittelsen HarsemBorghild Roald
Sep 8, 2004·Journal of the Society for Gynecologic Investigation·Berthold Huppertz, John C P Kingdom
Jun 11, 2005·Science·Christopher W Redman, Ian L Sargent
Aug 20, 2005·Circulation Research·Erdenechimeg ShagdarsurenDominik N Muller
Sep 20, 2005·Lancet·James M Roberts, Hilary Gammill
Aug 23, 2006·The Journal of Experimental Medicine·Guillermina GirardiJane E Salmon
Sep 8, 2006·The New England Journal of Medicine·Marshall D Lindheimer, Jason G Umans
Sep 26, 2006·The Journal of Clinical Investigation·Kristy Red-HorseSusan J Fisher
Feb 10, 2007·Reproductive Biology and Endocrinology : RB&E·Laura LunghiFortunato Vesce
Apr 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah J GermainChristopher W Redman
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Michelle HladunewichRichard Lafayette

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Citations

Jun 10, 2011·Physiological Genomics·Toshihiro KonnoMichael J Soares
Jul 14, 2012·The Journal of Reproduction and Development·Michael J SoaresM A Karim Rumi
Nov 26, 2010·Expert Review of Vaccines·Carla HerbertsMarijke Faas
Jan 3, 2013·American Journal of Reproductive Immunology : AJRI·Florian Herse, Babbette LaMarca
Mar 25, 2015·Molecular Immunology·Jean F RegalRichard M Burwick
Oct 15, 2013·Journal of Reproductive Immunology·Anne Cathrine StaffChristopher W G Redman
Oct 18, 2014·Archives of Gynecology and Obstetrics·Mohamed Salah RhimRaja Felah
Aug 27, 2011·Blood·John C P Kingdom, Sascha Drewlo
Jan 22, 2014·Hypertension·Serra E ElliottPatrick S Daugherty
Mar 1, 2013·Expert Review of Endocrinology & Metabolism·Filiberto Maria SeveriFelice Petraglia
Sep 25, 2020·American Journal of Obstetrics and Gynecology·Anne Cathrine StaffMeryam Sugulle
Feb 9, 2021·Human Immunology·Ai-Ris Y CollierS Ananth Karumanchi

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