Tropisetron attenuates cardiac injury in a rat trauma-hemorrhage model

Shock
Fu-Chao LiuHuang-Ping Yu

Abstract

Tropisetron is widely used for antiemesis. Recent evidence shows that tropisetron possesses anti-inflammatory properties. Protein kinase B (Akt) is known to play an important role in negating proinflammatory response in injury. The aim of this study was to determine whether tropisetron provides cardioprotection mediated via an Akt-dependent pathway in trauma-hemorrhaged animals. Male Sprague-Dawley rats underwent trauma-hemorrhage and resuscitation. Tropisetron (1 mg/kg) with or without a PI3K inhibitor (wortmannin, 1 mg/kg) or vehicle was administered intravenously during the resuscitation. At 24 h after either the trauma-hemorrhage or sham operation, the cardiac function parameters (cardiac output, left ventricle pressure variability) were measured. Cardiac myeloperoxidase activity, interleukin 6 and intercellular adhesion molecule 1 levels, Akt activity, and apoptosis were measured. One-way analysis of variance and Tukey test were used for statistical analysis. Cardiac function was depressed and cardiac myeloperoxidase activity, interleukin 6 and intercellular adhesion molecule 1 levels, and cardiac apoptosis were markedly increased after trauma-hemorrhage. Administration of tropisetron significantly improved cardiac functio...Continue Reading

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Citations

May 20, 2014·Shock·Fu-Chao LiuHuang-Ping Yu
Jul 6, 2016·Shock·Maximilian WenigerIrshad H Chaudry
Mar 21, 2013·The Journal of Trauma and Acute Care Surgery·Fu-Chao LiuHuang-Ping Yu
Sep 20, 2019·Journal of Cellular Biochemistry·Mohsen RashidiSayed M Hosseini
Jan 17, 2021·International Journal of Molecular Sciences·Birte WeberMiriam Kalbitz

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