Tropism and innate host responses of the 2009 pandemic H1N1 influenza virus in ex vivo and in vitro cultures of human conjunctiva and respiratory tract.

The American Journal of Pathology
Michael C W ChanJ S Malik Peiris

Abstract

The novel pandemic influenza H1N1 (H1N1pdm) virus of swine origin causes mild disease but occasionally leads to acute respiratory distress syndrome and death. It is important to understand the pathogenesis of this new disease in humans. We compared the virus tropism and host-responses elicited by pandemic H1N1pdm and seasonal H1N1 influenza viruses in ex vivo cultures of human conjunctiva, nasopharynx, bronchus, and lung, as well as in vitro cultures of human nasopharyngeal, bronchial, and alveolar epithelial cells. We found comparable replication and host-responses in seasonal and pandemic H1N1 viruses. However, pandemic H1N1pdm virus differs from seasonal H1N1 influenza virus in its ability to replicate in human conjunctiva, suggesting subtle differences in its receptor-binding profile and highlighting the potential role of the conjunctiva as an additional route of infection with H1N1pdm. A greater viral replication competence in bronchial epithelium at 33 degrees C may also contribute to the slight increase in virulence of the pandemic influenza virus. In contrast with highly pathogenic influenza H5N1 virus, pandemic H1N1pdm does not differ from seasonal influenza virus in its intrinsic capacity for cytokine dysregulation. C...Continue Reading

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Citations

Jun 19, 2010·The New England Journal of Medicine·Benjamin J CowlingJoseph S M Peiris
May 7, 2010·The New England Journal of Medicine·Edgar BautistaKarl G Nicholson
May 7, 2011·Surgical Infections·Kristen C Sihler, Pauline K Park
Jul 26, 2012·The Journal of Infectious Diseases·Viola K WeinheimerAndreas C Hocke
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Jun 9, 2012·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·A LaqmaniM Regier
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