Abstract
Tropomyosin is a major regulatory protein of contractile systems and cytoskeleton, an actin-binding protein that positions laterally along actin filaments and modulates actin-myosin interaction. About 40 tropomyosin isoforms have been found in a variety of cytoskeleton systems, not necessarily connected with actin-myosin interaction and contraction. Involvement of specific tropomyosin isoforms in the regulation of key cell processes was shown, and specific features of tropomyosin genes and protein structure have been investigated with molecular biology and genetics approaches. However, the mechanisms underlying the effects of tropomyosin on cytoskeleton dynamics are still unclear. As tropomyosin is primarily an F-actin-binding protein, it is important to understand how it interacts both with actin and actin-binding proteins functioning in muscles and cytoskeleton to regulate actin dynamics. This review focuses on biochemical data on the effects of tropomyosin on actin assembly and dynamics, as well as on the modulation of these effects by actin-binding proteins. The data indicate that tropomyosin can efficiently regulate actin dynamics via allosteric conformational changes within actin filaments.
Citations
Jul 5, 2016·Journal of Muscle Research and Cell Motility·Wenjun ZhengBipasha Barua
Dec 23, 2017·Toxins·Mingxing FengZhaonong Hu
Mar 4, 2018·Cytoskeleton·Bipasha BaruaSarah E Hitchcock-DeGregori
Oct 20, 2018·Journal of Cell Science·Catherine ChengVelia M Fowler
Sep 11, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sergey Y BershitskyAlexander M Matyushenko
May 16, 2019·Proteins·Wenjun Zheng, Han Wen
Sep 20, 2019·Journal of Muscle Research and Cell Motility·Galina V KopylovaAndrey K Tsaturyan
Jul 3, 2020·Molecular Biology of the Cell·Paola ZambonMohan K Balasubramanian
Jul 9, 2020·Biophysics Reviews·Miro JancoPeter W Gunning
Jul 5, 2019·Journal of Muscle Research and Cell Motility·Joanna Moraczewska
Feb 23, 2020·Biochemistry. Biokhimii︠a︡·A M Matyushenko, D I Levitsky
Aug 18, 2020·Wellcome Open Research·Saravanan PalaniMohan K Balasubramanian
Oct 11, 2019·The Journal of Cell Biology·Saravanan PalaniMohan K Balasubramanian
Nov 19, 2020·Protein Science : a Publication of the Protein Society·Dmitri TolkatchevAlla S Kostyukova
Nov 22, 2020·International Journal of Molecular Sciences·Marina A MarchenkoAlexander M Matyushenko
Mar 12, 2021·Developmental Biology·Bridget T Jacques-FrickeLaura S Gammill
Apr 1, 2021·Scientific Reports·Fei WangShuchun Chen
Jun 3, 2021·International Journal of Molecular Sciences·Marina MarchenkoAlexander Matyushenko
Jul 6, 2021·Frontiers in Cell and Developmental Biology·Xiaoting ZhaoWentao Yue
Aug 3, 2021·Archives of Biochemistry and Biophysics·Marina A MarchenkoDmitrii I Levitsky
Aug 12, 2019·ACS Biomaterials Science & Engineering·Yan-Lei FanXi-Qiao Feng