Tropomyosin diffusion over actin subunits facilitates thin filament assembly

Structural Dynamics
Stefan FischerWilliam Lehman

Abstract

Coiled-coil tropomyosin binds to consecutive actin-subunits along actin-containing thin filaments. Tropomyosin molecules then polymerize head-to-tail to form cables that wrap helically around the filaments. Little is known about the assembly process that leads to continuous, gap-free tropomyosin cable formation. We propose that tropomyosin molecules diffuse over the actin-filament surface to connect head-to-tail to partners. This possibility is likely because (1) tropomyosin hovers loosely over the actin-filament, thus binding weakly to F-actin and (2) low energy-barriers provide tropomyosin freedom for 1D axial translation on F-actin. We consider that these unique features of the actin-tropomyosin interaction are the basis of tropomyosin cable formation.

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Citations

Sep 25, 2016·Archives of Biochemistry and Biophysics·Michael J RynkiewiczWilliam Lehman
Apr 5, 2016·Structural Dynamics·George N Phillips, José N Onuchic
Oct 10, 2018·Transboundary and Emerging Diseases·Haranahally Vasanthachar ManjunathacharSrikant Ghosh
Jul 5, 2019·Journal of Muscle Research and Cell Motility·Joanna Moraczewska

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