PMID: 377290Apr 1, 1979Paper

Tropomyosin synthesis accompanies formation of actin filaments in embryonal carcinoma cells induced to differentiate by hexamethylene bisacetamide

Proceedings of the National Academy of Sciences of the United States of America
D PaulinM Yaniv

Abstract

Hexamethylene bisacetamide (HMBA) induces in vitro the cytodifferentiation of PCC3/A/1 mouse embryonal carcinoma (EC) cells. In EC cells, actin is associated with surface structures but microfilament bundles are not seen. After 2 days of HMBA treatment, rounded EC cells are converted to flat adhesive ones with a developed cytoskeleton containing actin and tropomyosin. The ratio of actin to total proteins is constant in EC cells and their HMBA derivatives; but a striking difference is observed for one of the newly synthesized proteins (Mr 34,000) identified as tropomyosin. Synthesis of tropomyosin is followed by its association with actin microfilament bundles, as revealed by indirect immunofluorescence microscopy with specific antibodies.

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Citations

Jan 1, 1983·Molecular and Cellular Biochemistry·G P Côté
Jan 1, 1988·Journal of Molecular Evolution·S ColoteJ P Liautard
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M Hendricks, H Weintraub
Aug 1, 1988·The Journal of Cell Biology·J J LinJ L Lin
Sep 1, 1990·Journal of Neurochemistry·C Faivre-SarrailhA Rabié
Apr 29, 1982·Biochimica Et Biophysica Acta·C L LeonardiR W Rubin
Feb 15, 1983·Journal of Molecular Biology·K Talbot, A R MacLeod
Apr 1, 1981·Experimental Cell Research·S LinderN R Ringertz
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Jan 1, 1982·Differentiation; Research in Biological Diversity·N ForestD Paulin
Jul 5, 1983·Journal of Molecular Biology·A R MacLeod, K Talbot
Mar 22, 1990·Nature·M Way, A Weeds
Dec 1, 1984·Cancer·P A Marks, R A Rifkind
Aug 1, 1983·Journal of Cellular Physiology·C Cremisi
Jun 1, 1986·Molecular and Cellular Biology·C C Karlik, E A Fyrberg
Jan 1, 1982·Differentiation; Research in Biological Diversity·D PaulinM Osborn

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