Troubling outcomes from population-level analysis of surgery for upper tract urothelial carcinoma

Urology
Robert AbouassalyAntonio Finelli

Abstract

To review the surgical management of upper tract urothelial carcinoma (UTUC) on a population level. UTUC accounts for 5% of urothelial malignancies, making it less amenable to single-center reporting. Complete nephroureterectomy is the standard of care, and increasing evidence has shown that a suboptimal surgical technique is associated with an adverse prognosis. We obtained information for all patients diagnosed with UTUC (n = 830) and those treated surgically (n = 680) in the province of Ontario, Canada from the Ontario Cancer Registry from 1995 to 2004. Demographic, treatment, and vital status information was obtained for all patients, and pathology reports were available for 422 patients. The primary outcome was overall survival. The secondary outcomes included measures of surgical quality (ie, number of lymph nodes sampled, ureteral length excised, surgical margin status, and 30-day mortality) and disease-specific survival. The unadjusted 5-year overall survival rate was 57.2%, with a median survival of 72.5 months. For those treated surgically, the 30-day mortality rate was 1.8%, and the positive surgical margin rate was 8.5%. Lymph nodes were identified in only 27% of the specimens, with a median yield of 1 (range 1-15)....Continue Reading

References

Jan 1, 1990·Journal of Clinical Epidemiology·S G Hilsenbeck
Mar 1, 1981·American Journal of Public Health·C PercyL Gloeckler
Jul 24, 2007·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jay S Keystone, Jody H Hershey
Jan 22, 2009·Cancer·Vitaly MargulisUNKNOWN Upper Tract Urothelial Carcinoma CollaborationThe Upper Tract Urothelial Carcinoma Collaboration

❮ Previous
Next ❯

Citations

Aug 26, 2014·Der Urologe. Ausg. A·S RauschA Stenzl
Dec 18, 2013·Clinical Genitourinary Cancer·Alexander KarlUNKNOWN Urologic Diseases in America Project
Apr 20, 2014·Journal of Endourology·Alexander TsivianA Ami Sidi
Aug 27, 2011·Therapeutic Advances in Urology·Mesut RemziChristian Seitz
Aug 18, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hiroshi KitamuraTaiji Tsukamoto
Apr 22, 2011·International Journal of Clinical Oncology·Tsunenori Kondo, Kazunari Tanabe
Sep 27, 2012·World Journal of Urology·Harun FajkovicShahrokh F Shariat
Nov 1, 2011·Actas urologicas españolas·M RouprêtUNKNOWN European Association of Urology Guideline Group for urothelial cell carcinoma of the upper urinary tract
Jan 25, 2016·Urologic Oncology·Anand MohapatraSeth A Strope
Apr 2, 2013·European Urology·Morgan RouprêtUNKNOWN European Association of Urology
May 1, 2010·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·P ColinX Leroy
Jul 30, 2011·European Urology·Marco RoscignoRichard Zigeuner
Sep 12, 2015·Japanese Journal of Clinical Oncology·Takeshi HashimotoMasaaki Tachibana
Jul 26, 2014·Journal of Surgical Oncology·Jun Nyung LeeBup Wan Kim
Apr 29, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Pengchao LiChangjun Yin
Mar 16, 2018·Expert Review of Anticancer Therapy·Alejo Rodriguez-Vida, Joaquim Bellmunt
Mar 17, 2016·World Journal of Nephrology·Julia V Fiuk, Brad F Schwartz
Mar 26, 2019·BJU International·Stefania ZamboniUNKNOWN European Association of Urology - Young Academic Urologists (EAU-YAU), Urothelial carcinoma working group
May 28, 2019·Expert Review of Anticancer Therapy·Mehdi Kardoust PariziShahrokh F Shariat
Oct 27, 2015·Journal of Hematology & Oncology·Alejo Rodriguez-VidaHendrik-Tobias Arkenau

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.