Trout CC chemokines: comparison of their sequences and expression patterns

Molecular Immunology
Kerry J Laing, C J Secombes

Abstract

Several thousand EST sequences were recently made available in the EMBL sequence database from the rainbow trout Oncorhynchus mykiss. BLAST based searches were utilised to identify sequences resembling mammalian CC chemokines within these ESTs. Fifteen new and unique CC chemokine-like sequences were identified for trout, bringing the total of known CC chemokine sequences in trout to 18 when including those already published. Some of these trout chemokines appeared highly related (in pairs) suggesting recent duplication events or tight evolutionary constraints. Phylogenetically, the trout chemokine sequences grouped with both inducible and constitutive mammalian CC chemokine subtypes, suggesting early divergence of these functional groups. Expression analyses on gill and head kidney show constitutive expression of many of these trout CC chemokines in these lymphoid-rich tissues. However, induction of some of the chemokines structurally related to 'inducible' CC chemokines was observed in a trout macrophage-like cell line (RTS-11) in response to stimulation with recombinant TNFalpha.

References

Mar 1, 1970·Journal of Molecular Biology·S B Needleman, C D Wunsch
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·M D KrathwohlK H Fife
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·M D GunnL T Williams
Jan 23, 1999·Immunological Reviews·B DixonP Parham
Apr 27, 2000·The Journal of Biological Chemistry·W WangA Zlotnik
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·S A LutherJ G Cyster
Mar 7, 2001·European Journal of Biochemistry·K J LaingC J Secombes
Nov 7, 2001·Developmental and Comparative Immunology·J ZouC J Secombes
Dec 26, 2001·Bioinformatics·S KumarM Nei
Jun 24, 2003·Developmental and Comparative Immunology·J ZouC J Secombes
Aug 7, 2003·Trends in Biotechnology·Aleksander Patrzykat, Susan E Douglas
Sep 26, 2003·Scandinavian Journal of Immunology·T S Uinuk-OolJ Klein

❮ Previous
Next ❯

Citations

Sep 8, 2012·Fish Physiology and Biochemistry·Juan FengYunxin Wang
Nov 30, 2013·Fish & Shellfish Immunology·Jae-Sung RheeJae-Seong Lee
Jun 14, 2005·Molecular Immunology·Puttharat BaoprasertkulZhanjiang Liu
Mar 4, 2014·Advances in Wound Care·Manuela Martins-GreenLei Wang
Sep 12, 2014·Proceedings. Biological Sciences·Adam KaneLuke McNally
Nov 19, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Richard F ShoreSteve Fryday
Nov 19, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Richard J CuthbertRhys E Green
Nov 17, 2015·Biology·Steve Bird, Carolina Tafalla
Mar 19, 2011·Developmental and Comparative Immunology·Alí Alejo, Carolina Tafalla
Jan 11, 2011·Fish & Shellfish Immunology·Tomoyuki OdakaOsamu Nakamura
Jun 20, 2008·Fish & Shellfish Immunology·Chris Secombes
Oct 20, 2006·Molecular Immunology·Santiago Fernandez GonzalezAndrew Cossins
Jun 10, 2005·Xenotransplantation·Debbie A PlouffeMiodrag Belosevic
Oct 24, 2006·Cytokine·Anand AnbarasuSethumadhavan Rao
Mar 3, 2006·Developmental and Comparative Immunology·Baolong BaoZhanjiang Liu
Mar 1, 2006·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Ram Savan, Masahiro Sakai
Dec 3, 2014·Developmental and Comparative Immunology·Unni GrimholtBen F Koop
Nov 16, 2013·Molecular Immunology·Prasanth BhattJesu Arockiaraj

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.