TRP Channel Involvement in Salivary Glands-Some Good, Some Bad

Cells
Xibao LiuIndu Ambudkar

Abstract

Salivary glands secrete saliva, a mixture of proteins and fluids, which plays an extremely important role in the maintenance of oral health. Loss of salivary secretion causes a dry mouth condition, xerostomia, which has numerous deleterious consequences including opportunistic infections within the oral cavity, difficulties in eating and swallowing food, and problems with speech. Secretion of fluid by salivary glands is stimulated by activation of specific receptors on acinar cell plasma membrane and is mediated by an increase in cytosolic [Ca2+] ([Ca2+]i). The increase in [Ca2+]i regulates a number of ion channels and transporters that are required for establishing an osmotic gradient that drives water flow via aquaporin water channels in the apical membrane. The Store-Operated Ca2+ Entry (SOCE) mechanism, which is regulated in response to depletion of ER-Ca2+, determines the sustained [Ca2+]i increase required for prolonged fluid secretion. Core components of SOCE in salivary gland acinar cells are Orai1 and STIM1. In addition, TRPC1 is a major and non-redundant contributor to SOCE and fluid secretion in salivary gland acinar and ductal cells. Other TRP channels that contribute to salivary flow are TRPC3 and TRPV4, while pres...Continue Reading

References

Nov 11, 1990·Cell Calcium·J W Putney
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·P D WesC Montell
Feb 1, 2000·The Journal of Biological Chemistry·X LiuI S Ambudkar
Apr 11, 2000·International Journal of Radiation Biology·L J ZeilstraR P Coppes
Sep 6, 2000·Nature Genetics·R BargalG Bach
Mar 15, 2002·Cell·Craig MontellVeit Flockerzi
Mar 15, 2002·Cell·Andrea M PeierArdem Patapoutian
Mar 28, 2002·Physiological Reviews·Baruch Minke, Boaz Cook
Nov 13, 2002·The Journal of Biological Chemistry·Anne-Laure PerraudAndrew M Scharenberg
May 24, 2003·Science·Elizabeth D Prescott, David Julius
Jun 12, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·A VissinkR P Coppes
Jul 3, 2003·Nature Reviews. Neuroscience·Ardem PatapoutianVeena Viswanath
Mar 30, 2004·Neuron·Michael BandellArdem Patapoutian
Nov 25, 2004·The Journal of Biological Chemistry·Anne-Laure PerraudAndrew M Scharenberg
Feb 16, 2005·Annual Review of Physiology·James E MelvinTed Begenisich
Feb 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Beiying Liu, Feng Qin
Feb 25, 2005·Science's STKE : Signal Transduction Knowledge Environment·Craig Montell
Apr 12, 2005·European Journal of Oral Sciences·Nicolas DelaleuMarkus M Koller
Apr 23, 2005·The Journal of Physiology·Karl P Schlingmann, Thomas Gudermann
Apr 27, 2005·Nature Neuroscience·Tibor RohácsDiomedes E Logothetis
Jun 21, 2005·Pflügers Archiv : European journal of physiology·David J Beech
Jul 2, 2005·International Journal of Radiation Oncology, Biology, Physics·Antonius W T KoningsArjan Vissink
Jul 12, 2005·Current Biology : CB·Jen LiouTobias Meyer
Oct 1, 2005·Science·Akira FutatsugiKatsuhiko Mikoshiba
Dec 1, 2005·The Journal of Biological Chemistry·Andreas GasserAndreas H Guse
Apr 11, 2006·British Journal of Pharmacology·Robert KraftChristian Harteneck
Jan 20, 2007·Biochemical Society Transactions·I S Ambudkar
Mar 14, 2007·The Journal of Biological Chemistry·Julia F DoernerChristian H Wetzel

❮ Previous
Next ❯

Citations

May 31, 2019·International Journal of Molecular Sciences·Rosario González-MuñizIsabel Gómez-Monterrey
Mar 7, 2021·International Journal of Molecular Sciences·María Ángeles BonacheRosario González-Muñiz
Jun 10, 2021·ELife·Karla Marie Márquez-NoguerasSilvia Nj Moreno
Jun 9, 2020·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·A KanewskaM Takeuchi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.