TRP channel proteins and signal transduction

Physiological Reviews
Baruch Minke, Boaz Cook

Abstract

TRP channel proteins constitute a large and diverse family of proteins that are expressed in many tissues and cell types. This family was designated TRP because of a spontaneously occurring Drosophila mutant lacking TRP that responded to a continuous light with a transient receptor potential (hence TRP). In addition to responses to light, TRPs mediate responses to nerve growth factor, pheromones, olfaction, mechanical, chemical, temperature, pH, osmolarity, vasorelaxation of blood vessels, and metabolic stress. Furthermore, mutations in several members of TRP-related channel proteins are responsible for several diseases, such as several tumors and neurodegenerative disorders. TRP-related channel proteins are found in a variety of organisms, tissues, and cell types, including nonexcitable, smooth muscle, and neuronal cells. The large functional diversity of TRPs is also reflected in their diverse permeability to ions, although, in general, they are classified as nonselective cationic channels. The molecular domains that are conserved in all members of the TRP family constitute parts of the transmembrane domains and in most members also the ankyrin-like repeats at the NH2 terminal of the protein and a "TRP domain" at the COOH ter...Continue Reading

References

Sep 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R F Irvine
May 1, 1992·The Journal of General Physiology·E Nasi, M P Gomez
Jan 1, 1991·Annual Review of Cell Biology·D P SmithC S Zuker
Oct 1, 1991·The Journal of General Physiology·E Suss-TobyB Minke
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B MinkeZ Selinger
Jan 1, 1989·Annual Review of Neuroscience·K W Yau, D A Baylor
Dec 1, 1989·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·P Hochstrate
Sep 21, 1989·Nature·M J Berridge, R F Irvine
Sep 1, 1989·The Journal of General Physiology·E SussB Minke
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·O DevaryZ Selinger
Jul 1, 1986·The Journal of General Physiology·R PayneA Fein
Oct 18, 1969·Nature·D J Cosens, A Manning
Aug 24, 1984·Science·M Wilcox, N Franceschini
Mar 1, 1982·The Journal of General Physiology·B Minke
Nov 15, 1995·The Biochemical Journal·M J Berridge
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·P D WesC Montell
Jan 1, 1995·Annual Review of Neuroscience·R RanganathanC S Zuker
Jul 28, 1995·The Journal of Biological Chemistry·L Y BourguignonN R Brandt
Dec 1, 1994·The Journal of General Physiology·A PeretzB Minke
Jan 15, 1995·The Biochemical Journal·Y Hu, W P Schilling
Nov 1, 1994·The American Journal of Physiology·L VacaW P Schilling
Mar 1, 1994·The Journal of General Physiology·R C Hardie, B Minke
Nov 24, 1993·Biochimica Et Biophysica Acta·Z SelingerB Minke
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·I MasaiY Hotta
Jun 22, 1993·Proceedings. Biological Sciences·R C HardieB Minke
Dec 1, 1995·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·R C Hardie
Feb 9, 1996·The Journal of Biological Chemistry·W G SinkinsW P Schilling

❮ Previous
Next ❯

Citations

May 29, 2014·The Journal of Clinical Investigation·Sergio E ChiarellaGökhan M Mutlu
Nov 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Dirk PrawittReinhold Penner
Jan 28, 2004·The Journal of General Physiology·Andriy V YerominMichael D Cahalan
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Hiu-Yee KwanXiaoqiang Yao
Jul 14, 2004·The Journal of Experimental Medicine·Alexander J StokesHelen Turner
Nov 16, 2004·The Journal of Biological Chemistry·Sunitha BollimunthaManuchair Ebadi
Nov 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·M SethG Inesi
Jan 18, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Qihai GuLu-Yuan Lee
Jul 30, 2005·Pflügers Archiv : European journal of physiology·Oleksandr PlatoshynJason X-J Yuan
Feb 8, 2006·Annual Review of Physiology·Baruch Minke, Moshe Parnas
Jun 8, 2006·Annual Review of Biochemistry·Krzysztof Palczewski
Nov 14, 2006·The Journal of Clinical Investigation·Koichiro KuwaharaEric N Olson
Dec 28, 2006·The Journal of General Physiology·Moshe ParnasBaruch Minke
Jan 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Anna KlodaBoris Martinac
Jan 11, 2008·American Journal of Physiology. Cell Physiology·Dan ShanJohn C Chatham
Apr 9, 2008·The Journal of Biological Chemistry·Tomohiro Numata, Yasunobu Okada
Apr 22, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Wenju LuJ T Sylvester
May 7, 2008·American Journal of Respiratory Cell and Molecular Biology·Ashwini S SabnisChristopher A Reilly
May 21, 2008·Proceedings of the National Academy of Sciences of the United States of America·Vera Y Moiseenkova-BellTheodore G Wensel
Jul 31, 2008·Pflügers Archiv : European journal of physiology·Mohamed TrebakJames W Putney
Nov 27, 2008·The Journal of Clinical Investigation·Fumitaka FujitaMakoto Tominaga
Feb 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Moshe ParnasBaruch Minke
Aug 10, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Gongyong PengJian Wang
Oct 5, 2011·Pharmacological Reviews·John A SalonKrzysztof Palczewski
Dec 29, 2011·Frontiers in Bioscience (Landmark Edition)·Biswaranjan PaniBrij B Singh
Jun 14, 2012·International Journal of Molecular Medicine·Hao ZhangYuchun Gu
Oct 15, 2013·The Journal of Physiological Sciences : JPS·Masayuki TakaishiMakoto Tominaga
Jan 7, 2015·International Journal of Molecular Sciences·Chunfa Huang, Carl Freter
Feb 10, 2004·The Journal of Physiology·François J MichelLouis-Eric Trudeau

❮ Previous
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