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Trp53 affects the developmental anomaly of clefts of the palate in irradiated mouse embryos but not clefts of the lip with or without the palate

Radiation Research

Dec 8, 2006

Shota NaraiRyo Kominami

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Abstract

Trp53-deficient mice exhibit increased incidences of developmental anomalies when irradiated, probably due to lack of Trp53-dependent apoptosis. A/J strain-derived CL/Fr mice develop clefts of the lip with or without the palate (CL/P) in approximately one-fifth of the embryos. We produc...read more

Mentioned in this Paper

TP53 gene
Embryo
Tissue Membrane
Mice, Inbred BALB C
Maxilla
Uterus
Cessation of Life
Cleft Palate, Isolated
Properdin Deficiency, X-LINKED
Weighing Patient
Paper Details
References
  • References17
  • Citations2
12
  • References17
  • Citations2
1

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Trp53 affects the developmental anomaly of clefts of the palate in irradiated mouse embryos but not clefts of the lip with or without the palate

Radiation Research

Dec 8, 2006

Shota NaraiRyo Kominami

PMID: 17149979

DOI: 10.1667/rr0644.1

Abstract

Trp53-deficient mice exhibit increased incidences of developmental anomalies when irradiated, probably due to lack of Trp53-dependent apoptosis. A/J strain-derived CL/Fr mice develop clefts of the lip with or without the palate (CL/P) in approximately one-fifth of the embryos. We produc...read more

Mentioned in this Paper

TP53 gene
Embryo
Tissue Membrane
Mice, Inbred BALB C
Maxilla
Uterus
Cessation of Life
Cleft Palate, Isolated
Properdin Deficiency, X-LINKED
Weighing Patient

Feeds With Similar Papers

Hereditary Cancer Syndromes

Hereditary cancer syndromes comprise 5% of all cancers and have an increased risk of early onset and of multiple or bilateral malignancies. Here is the latest research on hereditary cancer syndromes.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

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Paper Details
References
  • References17
  • Citations2
12
  • References17
  • Citations2
1

Download from

Publisher
PubMed
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