TRPA1 Channels Modify TRPV1-Mediated Current Responses in Dorsal Root Ganglion Neurons

Frontiers in Physiology
Takayoshi MasuokaTakaharu Ishibashi

Abstract

The transient receptor potential vanilloid 1 (TRPV1) channel is highly expressed in a subset of sensory neurons in the dorsal root ganglia (DRG) and trigeminal ganglia of experimental animals, responsible for nociception. Many researches have revealed that some TRPV1-positive neurons co-express the transient receptor potential ankyrin 1 (TRPA1) channel whose activities are closely modulated by TRPV1 channel. However, it is less investigated whether the activities of TRPV1 channel are modulated by the presence of TRPA1 channel in primary sensory neurons. This study clarified the difference in electrophysiological responses induced by TRPV1 channel activation between TRPA1-positive and TRPA1-negative DRG. TRPV1 and TRPA1 channel activations were evoked by capsaicin (1 μM), a TRPV1 agonist, and allyl isothiocyanate (AITC; 500 μM), a TRPA1 agonist, respectively. Capsaicin perfusion for 15 s caused a large inward current without a desensitization phase at a membrane potential of -70 mV in AITC-insensitive DRG (current density; 29.6 ± 5.6 pA/pF, time constant of decay; 12.8 ± 1.8 s). The capsaicin-induced currents in AITC-sensitive DRG had a small current density (12.7 ± 2.9 pA/pF) with a large time constant of decay (24.3 ± 5.4 s). ...Continue Reading

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Citations

Jun 23, 2018·Journal of Cell Science·Samuel M BestallLucy F Donaldson
May 19, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Fahima MayerGregory W Aponte
Feb 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xingjuan ChenAlexander G Obukhov
Jan 18, 2020·International Journal of Molecular Sciences·Mária DuxKarl Messlinger
Jun 18, 2020·Scientific Reports·Masayoshi KawaseMakoto Kanzaki
Jan 12, 2021·Frontiers in Cellular Neuroscience·Takayoshi MasuokaTakaharu Ishibashi
Apr 4, 2021·International Journal of Molecular Sciences·Mee-Ra RhyuVijay Lyall
Apr 6, 2021·Acta Physiologica·Clara HoebartStefan Heber
May 28, 2021·Acta Physiologica·Romain Guinamard, Thomas Hof
Aug 28, 2021·Biomolecules·Jenny WilzopolskiKristine Rossbach

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