TRPC Channels and Alzheimer's Disease

Advances in Experimental Medicine and Biology
Rui LuJunfeng Wang

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. The "amyloid hypothesis" is one of the predominant hypotheses for the pathogenesis of AD. Besides, tau protein accumulation, calcium homeostasis disruption, and glial cell activation are also remarkable features in AD. Recently, there are some reports showing that TRPC channels may function in AD development, especially TRPC6. In this chapter, we will discuss the evidence for the involvement of TRPC channels in Alzheimer's disease and the potential of therapeutics for AD based on TRPC channels.

Citations

May 1, 2020·Frontiers in Physiology·Chansik HongInsuk So
Feb 16, 2021·Frontiers in Cell and Developmental Biology·Sung-Min HwangYong Ho Kim
Feb 1, 2020·Pharmacology & Therapeutics·Hongbo WangMichael X Zhu
Jul 31, 2021·Frontiers in Cell and Developmental Biology·Ruxin XieXiaotang Fan

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