TRPC Channels and Parkinson's Disease

Advances in Experimental Medicine and Biology
Pramod SukumaranBrij B Singh

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder, which involves degeneration of dopaminergic neurons that are present in the substantia nigra pars compacta (SNpc) region. Many factors have been identified that could lead to Parkinson's disease; however, almost all of them are directly or indirectly dependent on Ca2+ signaling. Importantly, though disturbances in Ca2+ homeostasis have been implicated in Parkinson's disease and other neuronal diseases, the identity of the calcium channel remains elusive. Members of the transient receptor potential canonical (TRPC) channel family have been identified as a new class of Ca2+ channels, and it could be anticipated that these channels could play important roles in neurodegenerative diseases, especially in PD. Thus, in this chapter we have entirely focused on TRPC channels and elucidated its role in PD.

Citations

Jun 10, 2020·Cellular and Molecular Neurobiology·Yuyang SunBrij B Singh
Aug 9, 2020·Frontiers in Aging Neuroscience·Arkady UryashJose R Lopez
Feb 1, 2020·Pharmacology & Therapeutics·Hongbo WangMichael X Zhu
Apr 4, 2021·International Journal of Molecular Sciences·Anastasiia BohushAnna Filipek
Aug 28, 2021·Cells·Pramod SukumaranBrij B Singh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Related Papers

Antioxidants & Redox Signaling
Aracely Garcia-GarciaRodrigo Franco
European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
H LiuW Le
Drug Design, Development and Therapy
Liuqing MaWeien Yuan
© 2022 Meta ULC. All rights reserved