TRPC Channels and Stroke

Advances in Experimental Medicine and Biology
Junbo Huang

Abstract

TRPC channels play important roles in neuronal death/survival in ischemic stroke, vasospasm in hemorrhagic stroke, thrombin-induced astrocyte pathological changes, and also in the initiation of stroke by affecting blood pressure and atherogenesis. TRPCs' unique channel characters and downstream pathways make them possible new targets for stroke therapy. TRPC proteins have different functions in different cell types. Considering TRPCs' extensive distribution in various tissues and cell types, drugs targeting them could induce more complicated effects. More specific agonists/antagonists and antibodies are required for future study of TRPCs as potential targets for stroke therapy.

Citations

Mar 7, 2021·International Journal of Molecular Sciences·Shashank ShekharGeorge W Booz

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