TRPC Channels in Health and Disease

Advances in Experimental Medicine and Biology
Yilin TaiWei Shao

Abstract

This chapter offers a brief introduction of the functions of TRPC channels in non-neuronal systems. We focus on three major organs of which the research on TRPC channels have been most focused on: kidney, heart, and lung. The chapter highlights on cellular functions and signaling pathways mediated by TRPC channels. It also summarizes several inherited diseases in humans that are related to or caused by TRPC channel mutations and malfunction. A better understanding of TRPC channels functions and the importance of TRPC channels in health and disease should lead to new insights and discovery of new therapeutic approaches for intractable disease.

Citations

Apr 25, 2018·International Journal of Molecular Sciences·Raquibul Hasan, Xuming Zhang
Jan 25, 2020·Molecular Medicine Reports·Huijun ChengYoujun Zhou
Sep 3, 2020·Cells·Xingjuan ChenAlexander G Obukhov
Nov 20, 2020·Current Opinion in Physiology·Bernadett BacsaKlaus Groschner

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