TRPC3 cation channel plays an important role in proliferation and differentiation of skeletal muscle myoblasts.

Experimental & Molecular Medicine
Jin Seok WooEun Hui Lee

Abstract

During membrane depolarization associated with skeletal excitation-contraction (EC) coupling, dihydropyridine receptor [DHPR, a L-type Ca(2+) channel in the transverse (t)-tubule membrane] undergoes conformational changes that are transmitted to ryanodine receptor 1 [RyR1, an internal Ca(2+)-release channel in the sarcoplasmic reticulum (SR) membrane] causing Ca(2+) release from the SR. Canonical-type transient receptor potential cation channel 3 (TRPC3), an extracellular Ca(2+)-entry channel in the t-tubule and plasma membrane, is required for full-gain of skeletal EC coupling. To examine additional role(s) for TRPC3 in skeletal muscle other than mediation of EC coupling, in the present study, we created a stable myoblast line with reduced TRPC3 expression and without alpha1((S))DHPR (MDG/TRPC3 KD myoblast) by knock-down of TRPC3 in alpha1((S))DHPR-null muscular dysgenic (MDG) myoblasts using retrovirus-delivered small interference RNAs in order to eliminate any DHPR-associated EC coupling-related events. Unlike wild-type or alpha1((S))DHPR-null MDG myoblasts, MDG/TRPC3 KD myoblasts exhibited dramatic changes in cellular morphology (e.g., unusual expansion of both cell volume and the plasma membrane, and multi-nuclei) and fail...Continue Reading

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Citations

Oct 31, 2015·Cell Biology International·Gajalakshmi Ramanathan, Christine Mannhalter
Feb 22, 2012·Current Opinion in Pharmacology·Philippe Gailly
Jul 5, 2015·Biochemical and Biophysical Research Communications·Jin Seok WooEun Hui Lee
Mar 13, 2014·Biochemical and Biophysical Research Communications·Jin Seok WooEun Hui Lee
Sep 16, 2017·Experimental & Molecular Medicine·Chung-Hyun ChoEun Hui Lee
Oct 10, 2018·Pflügers Archiv : European journal of physiology·Takuro Numaga-TomitaMotohiro Nishida
Jan 15, 2014·BMB Reports·Zui PanJianjie Ma
Apr 5, 2020·Cells·Jun Hee ChoiEun Hui Lee
Oct 13, 2017·ACS Applied Materials & Interfaces·Serge OstrovidovAli Khademhosseini

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