TRPC3-interacting triadic proteins in skeletal muscle

The Biochemical Journal
Jin Seok WooEun Hui Lee

Abstract

The expression of TRPC3 (canonical-type transient receptor potential cation channel type 3) is tightly regulated during skeletal muscle cell differentiation, and a functional interaction between TRPC3 and RyR1 [(ryanodine receptor type 1), an SR (sarcoplasmic reticulum) Ca2+-release channel] regulates the gain of SR Ca2+ release during EC (excitation-contraction) coupling. However, it has not been possible to demonstrate direct protein-protein interactions between TRPC3 and RyR1. To identify possible candidate(s) for a linker protein(s) between TRPC3 and RyR1 in skeletal muscle, in the present study we performed MALDI-TOF (matrix-assisted laser-desorption ionization-time-of-flight) MS analysis of a cross-linked triadic protein complex from rabbit skeletal triad vesicles and co-immunoprecipitation assays using primary mouse skeletal myotubes. From these studies, we found that six triadic proteins, that are known to regulate RyR1 function and/or EC coupling [TRPC1, JP2 (junctophilin 2), homer, mitsugumin 29, calreticulin and calmodulin], interacted directly with TRPC3 in a Ca2+-independent manner. However we again found no direct interaction between TRPC3 and RyR1. TRPC1 was identified as a potential physical link between TRPC3 a...Continue Reading

References

Jul 7, 2000·The Journal of Biological Chemistry·B LintschingerK Groschner
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·Z ZhangM X Zhu
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·G VazquezJ W Putney
May 16, 2002·Biochemistry·Wan Jin JahngRobert R Rando
Sep 18, 2002·The Journal of Cell Biology·Clarisse VandebrouckPhilippe Gailly
May 9, 2003·The Journal of Biological Chemistry·Stephan PhilippMarkus Hoth
Jul 15, 2003·The Journal of Biological Chemistry·Carsten StrübingDavid E Clapham
Jan 1, 1964·Annual Review of Physiology·A J BRADY
Mar 23, 2004·The Journal of Biological Chemistry·Eun Hui LeeDo Han Kim
Sep 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ying YuJason X-J Yuan
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Gennady CherednichenkoIsaac N Pessah
Dec 18, 2004·American Journal of Physiology. Heart and Circulatory Physiology·S A ReadingJ E Brayden
Jun 23, 2005·Pflügers Archiv : European journal of physiology·Alexander DietrichThomas Gudermann
Jun 24, 2005·The Journal of Biological Chemistry·Tatiana K ZagranichnayaMitchel L Villereal
Feb 8, 2006·Annual Review of Physiology·I Scott RamseyDavid E Clapham
Feb 18, 2006·The Journal of Biological Chemistry·Eun Hui LeeP D Allen
Aug 22, 2006·Nature·Murali PrakriyaPatrick G Hogan
Oct 3, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Monu GoelWilliam P Schilling
Jan 24, 2007·Physiological Reviews·Bernd NiliusJohn A Peters
Mar 14, 2007·Cell Calcium·Indu S AmbudkarKwong Tai Cheng

❮ Previous
Next ❯

Citations

Jun 11, 2009·European Biophysics Journal : EBJ·Pierre Pouliquin, Angela Fay Dulhunty
Mar 12, 2009·Molecular and Cellular Biochemistry·Jin Seok WooEun Hui Lee
Oct 25, 2011·The Journal of Biological Chemistry·Lucia GoliniVincenzo Sorrentino
Dec 31, 2008·The Journal of General Physiology·Roger A BannisterKurt G Beam
Jun 16, 2011·Cardiovascular Research·Jessica SabourinEric Raddatz
Oct 23, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joel Abramowitz, Lutz Birnbaumer
Aug 5, 2011·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Daniel P JudgeKathryn R Wagner
Nov 21, 2008·Pharmacogenomics·Kathryn M Stowell
Oct 1, 2013·Pflügers Archiv : European journal of physiology·Keon Jin LeeEun Hui Lee
Mar 19, 2014·Trends in Molecular Medicine·Andrew P LandstromXander H T Wehrens
Jun 18, 2014·Cardiovascular Research·David L BeaversXander H T Wehrens
Sep 24, 2009·Cellular and Molecular Bioengineering·I-Chien LiaoKam W Leong
Mar 6, 2016·Cell Calcium·Michelle K TuLaura N Borodinsky
Oct 30, 2012·Biochemical and Biophysical Research Communications·Keon Jin LeeEun Hui Lee
Oct 12, 2010·Progress in Biophysics and Molecular Biology·Dong Woo SongDo Han Kim
Jun 18, 2010·Progress in Biophysics and Molecular Biology·Eun Hui Lee
Jul 8, 2008·Journal of Neuroimmunology·Masaharu Takamori
Dec 21, 2012·Annals of the New York Academy of Sciences·Masaharu Takamori
Jan 26, 2010·The Biochemical Journal·Jin Seok WooEun Hui Lee
Feb 22, 2012·Current Opinion in Pharmacology·Philippe Gailly
Jul 5, 2015·Biochemical and Biophysical Research Communications·Jin Seok WooEun Hui Lee
Jul 14, 2010·Biochimica Et Biophysica Acta·Hanna M PeltonenGeneviève Bart
Aug 5, 2015·Orphanet Journal of Rare Diseases·Henry RosenbergKathryn Stowell
Mar 13, 2014·Biochemical and Biophysical Research Communications·Jin Seok WooEun Hui Lee
Sep 16, 2017·Experimental & Molecular Medicine·Chung-Hyun ChoEun Hui Lee
Mar 3, 2010·Journal of Muscle Research and Cell Motility·J SabourinBruno Constantin
Oct 15, 2011·Muscle & Nerve·Kwok-Kuen CheungElla W Yeung
Nov 9, 2010·Communicative & Integrative Biology·Klaus Groschner
Apr 5, 2020·Cells·Jun Hee ChoiEun Hui Lee
Jul 15, 2017·Scientific Reports·Robert N CorrellJeffery D Molkentin
Oct 10, 2018·Pflügers Archiv : European journal of physiology·Takuro Numaga-TomitaMotohiro Nishida
Dec 10, 2016·Experimental & Molecular Medicine·Mei HuangEun Hui Lee
Dec 9, 2020·Experimental & Molecular Medicine·Jin Seok WooEun Hui Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.