TRPM2 variants and bipolar disorder risk: confirmation in a family-based association study

Bipolar Disorders
Chun XuJerry J Warsh

Abstract

Recent case-control studies implicate the transient receptor potential melastatin 2 (TRPM2) channel in conferring risk for bipolar disorder (BD), though the risk variants differed. As confounding effects of population structure could not be unequivocally ruled out as the basis for the discordance, we tested the association of TRPM2 with BD in a family design, which is immune to population stratification, for those TRPM2 single nucleotide polymorphisms (SNPs) previously reported as associated with BD. The exon 11 SNP (rs1556314) and four informative intronic SNPs (rs1785437, rs1618355, rs933151, and rs749909) were genotyped in 300 BD families by TaqMan allelic discrimination and results were analyzed using chi(2) test, transmission disequilibrium test, and pedigree-based association. SNP rs1556314 was also genotyped in our case-control sample set comprised of 184 BD and 195 healthy Caucasian subjects. The SNP rs1556314 in exon 11 was significantly associated with bipolar disorder type I (BD-I) (p = 0.011, p(permutation) = 0.015) in the case-control dataset and in the family design (p = 0.018, p(permutation) = 0.052, TDTPHASE). Interestingly, the C-T-A haplotype of SNPs rs1618355, rs933151, and rs749909 was significantly associat...Continue Reading

References

Oct 21, 1991·Nucleic Acids Research·D K Lahiri, J I Nurnberger
Oct 31, 2000·Genetic Epidemiology·N M LairdX Xu
Mar 10, 2001·Psychiatric Services : a Journal of the American Psychiatric Association·G M MacQueen, L T Young
Mar 20, 2001·Bipolar Disorders·J B Potash, J R DePaulo
May 30, 2001·American Journal of Medical Genetics·T G SchulzeM Rietschel
Oct 16, 2001·Nature Genetics·J P IoannidisD G Contopoulos-Ioannidis
Nov 3, 2001·Biological Psychiatry·I S YoonJ J Warsh
Mar 27, 2003·Bipolar Disorders·E Jane DaltonJames L Kennedy
May 3, 2003·The American Journal of Psychiatry·Frank BellivierMarion Leboyer
May 27, 2003·Cell Calcium·Anne-Laure PerraudAndrew M Scharenberg
Jan 13, 2004·Statistics in Medicine·Christoph LangeNan M Laird
Jan 24, 2004·American Journal of Human Genetics·Christoph LangeNan M Laird
Mar 31, 2004·Nature Genetics·Jonathan MarchiniPeter Donnelly
Dec 14, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Julian C Knight
Feb 18, 2005·Nature Reviews. Genetics·Joel N Hirschhorn, Mark J Daly
Mar 15, 2005·Bipolar Disorders·Marion LeboyerFrank Bellivier
Apr 2, 2005·Nature Reviews. Genetics·David J Hunter
May 11, 2005·Neuroscience Letters·Kyohei OtaniShigetoshi Kuroda
Jun 23, 2005·Molecular Psychiatry·G M MacQueenM Alda
Jul 26, 2005·Journal of Psychiatric Research·Stanley ZammitMichael J Owen
Oct 28, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Chun XuJerry J Warsh
Jan 13, 2006·Biological Psychiatry·Gregor HaslerHusseini K Manji
Jan 27, 2006·Genes, Brain, and Behavior·E P Hayden, J I Nurnberger
May 11, 2006·The Journal of Membrane Biology·B A Miller
May 11, 2006·American Journal of Human Genetics·Frank Dudbridge
May 16, 2006·Bipolar Disorders·Benício Noronha FreyFlávio Kapczinski
May 25, 2006·European Journal of Human Genetics : EJHG·Nick Craddock, Liz Forty
Jul 4, 2006·Biological Psychiatry·Kazuhisa MaedaAkira Sawa
Dec 2, 2006·Nature Reviews. Genetics·Kari HemminkiAsta Försti
Jan 5, 2007·European Journal of Human Genetics : EJHG·Sheng GuKenneth K Kidd
Feb 3, 2007·American Journal of Human Genetics·Ping-I LinEden R Martin
May 26, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·S RocheP McKeon
Jun 8, 2007·Nature·UNKNOWN NCI-NHGRI Working Group on Replication in Association StudiesFrancis S Collins
Jun 8, 2007·Nature·UNKNOWN Wellcome Trust Case Control Consortium
Nov 17, 2007·Science·Alexander GimelbrantAndrew Chess

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Citations

Feb 4, 2010·Pflügers Archiv : European journal of physiology·Bernd Nilius, Grzegorz Owsianik
Oct 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Greer S KirshenbaumJohn C Roder
Jan 10, 2013·Pharmacological Reviews·Chi-Tso ChiuDe-Maw Chuang
Dec 14, 2012·PloS One·Peilin YuJianbo Yue
Mar 24, 2010·Journal of Molecular Neuroscience : MN·Naomi L CookCorinna van den Heuvel
Jul 31, 2010·Expert Opinion on Therapeutic Targets·Lin-Hua JiangDavid J Beech
Jan 13, 2015·International Journal of Molecular Sciences·Merlin G ButlerAnn M Manzardo
Dec 8, 2010·The Journal of Physiology·Adriana Sumoza-Toledo, Reinhold Penner
Jul 4, 2012·Biochemical and Biophysical Research Communications·Bo ZengShang-Zhong Xu
May 28, 2011·Cell Calcium·Nobuaki TakahashiYasuo Mori
Jun 10, 2015·Journal of Affective Disorders·Kevin P KennedyBonnie Klimes-Dougan
Jul 6, 2016·Neuroscience and Biobehavioral Reviews·Giselli ScainiJoão Quevedo
Apr 20, 2018·Acta Pharmacologica Sinica·Jillian Corinne Belrose, Michael Frederick Jackson
Aug 2, 2011·Nature Reviews. Drug Discovery·Magdalene M MoranArpad Szallasi
Oct 24, 2019·CoDAS·Geise Corrêa FerreiraMaristela Julio Costa
Nov 16, 2019·Journal of Affective Disorders·Mikaela K DimickBenjamin I Goldstein

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