TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway

Journal of Cellular Physiology
Ricardo ArmisénAndrés Stutzin

Abstract

Altered expression of some members of the TRP ion channel superfamily has been associated with the development of pathologies like cancer. In particular, TRPM4 levels are reportedly elevated in diffuse large B-cell non-Hodgkin lymphoma, prostate, and cervical cancer. However, whether such changes in TRPM4 expression may be relevant to genesis or progression of cancer remains unknown. Here we show that reducing TRPM4 expression decreases proliferation of HeLa cells, a cervical cancer-derived cell line. In this cell line, constitutive TRPM4 silencing promoted GSK-3β-dependent degradation of β-catenin and reduced β-catenin/Tcf/Lef-dependent transcription. Conversely, overexpression of TRPM4 in T-REx 293 cells (a HEK293-derived cell line) increased cell proliferation and β-catenin levels. Our results identify TRPM4 as an important, unanticipated regulator of the β-catenin pathway, where aberrant signaling is frequently associated with cancer.

References

Jul 27, 2000·Annals of the New York Academy of Sciences·J Behrens
Nov 1, 2000·Cell·M Bienz, H Clevers
Feb 13, 2002·The American Journal of Pathology·Newton Alexander Chiang Shuek Wong, Massimo Pignatelli
Apr 6, 2002·Biological Chemistry·Helen BrantjesHans Clevers
Jun 5, 2003·Nature Reviews. Molecular Cell Biology·Derek M DykxhoornPhillip A Sharp
Jul 13, 2004·The Journal of Biological Chemistry·Tushar B DebRobert B Dickson
Sep 17, 2004·Nature Reviews. Genetics·Randall T MoonAjamete Kaykas
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Catriona Y Logan, Roel Nusse
Nov 20, 2004·Science·Pierre LaunayJean-Pierre Kinet
Dec 14, 2004·The Journal of Biological Chemistry·Bernd NiliusMichael X Zhu
Jun 17, 2006·Journal of Receptor and Signal Transduction Research·Elena FonfriaShaun McNulty
Sep 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·J C TapiaA F G Quest
Oct 13, 2006·Cellular Signalling·Matthias Bödding
Jan 16, 2007·Handbook of Experimental Pharmacology·R Vennekens, B Nilius
Jan 20, 2007·Biochemical Society Transactions·N PrevarskayaR Skryma
Jun 16, 2007·The Journal of Biological Chemistry·Paloma Goñi-OliverFélix Hernández
Jun 21, 2007·Annual Review of Biochemistry·Kartik Venkatachalam, Craig Montell
Jul 1, 2008·Breast Cancer Research and Treatment·Christine M CoticchiaMichael D Johnson
Dec 3, 2008·Cell Calcium·Takahiro ShimizuRudi Vennekens
Apr 16, 2009·Journal of Proteome Research·Sara ZanivanMatthias Mann
Sep 4, 2009·The Journal of Clinical Investigation·Martin KruseOlaf Pongs

❮ Previous
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Citations

Oct 16, 2012·Pflügers Archiv : European journal of physiology·J Marc SimardVolodymyr Gerzanich
Sep 21, 2011·Immunogenetics·Ammad Ahmad FarooqiShahzad Bhatti
Feb 9, 2016·Autoimmunity Reviews·Anantha Maharasi RamaKrishnan, Kavitha Sankaranarayanan
Feb 5, 2016·Seminars in Immunopathology·George ShapovalovNatalia Prevarskaya
Jun 3, 2014·Molecular Cancer·Ellyn N SchinkeGrant D Trobridge
Nov 23, 2015·Virchows Archiv : an International Journal of Pathology·Kasper Drimer BergGlen Kristiansen
Jul 22, 2014·British Journal of Pharmacology·Jun Ichikawa, Ryuji Inoue
May 6, 2015·Biochimica Et Biophysica Acta·Tarik SmaniJuan A Rosado
May 22, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Constanza BlancoOscar Cerda
Jun 30, 2012·American Journal of Physiology. Cell Physiology·C P MadsenE K Hoffmann
Jun 23, 2018·Pflügers Archiv : European journal of physiology·Dong Kun LeeSeong-Geun Hong
Jan 1, 2017·Current Molecular Biology Reports·Sven KappelAnna Borgström
Aug 24, 2018·International Journal of Molecular Sciences·Eleonora PersoonsJoris Vriens
Dec 10, 2020·Cells·Ivanka JimenezFelipe Simon
Feb 11, 2021·Biomolecules·Anna BorgströmPaulina Stokłosa
Dec 12, 2018·The Journal of Investigative Dermatology·Huijun WangZhimiao Lin
May 24, 2019·Medical Cannabis and Cannabinoids·Petra Luschnig, Rudolf Schicho
May 24, 2011·Biochemical and Biophysical Research Communications·Jocelyn MosqueraKatherine Marcelain

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