TRPM7 channel regulates ox-LDL-induced proliferation and migration of vascular smooth muscle cells via MEK-ERK pathways

FEBS Letters
Jinghan LinLiming Zhang

Abstract

Transient receptor potential melastatin 7 (TRPM7) plays a key role in the pathophysiological response of multiple cell types. However, the role of TRPM7 channels in ox-LDL-induced proliferation and migration of VSMC remains unclear. This study used the thoracic aorta VSMCs to explore the effects of ox-LDL on cell proliferation and migration and to investigate the underlying molecular mechanisms and signaling pathways. Data demonstrated that ox-LDL significantly increased TRPM7 activity, and induced VSMC proliferation and migration. VSMC proliferation and migration were inhibited by nonspecific TRPM7 blocker 2-APB or synthetic siRNA targeting TRPM7. Furthermore, the phosphorylation of ERK1/2 and MEK1/2 associated with cell proliferation and migration decreased in TRPM7-deficient VSMC. Therefore, TRPM7 may constitute a useful target for the treatment of atherosclerosis.

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Citations

Jun 20, 2018·International Journal of Molecular Sciences·Virginia Actis Dato, Gustavo Alberto Chiabrando
Apr 11, 2017·International Journal of Molecular Medicine·Sha LiXian Wu
Apr 19, 2019·International Journal of Molecular Sciences·Zhi-Guo ZouRhian M Touyz
Nov 22, 2020·Journal of Cellular and Molecular Medicine·Hui SunXianzhong Xiao

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