TRPV1 Channels in Immune Cells and Hematological Malignancies

Advances in Pharmacology
Sofia A OmariDominic P Geraghty

Abstract

Transient receptor potential vanilloid-1 (TRPV1) is a member of the TRP family of channels that are responsible for nociceptive, thermal, and mechanical sensations. Originally associated exclusively with sensory neurons, TRPV1 is now known to be present in almost all organs, including cells of the immune system, where TRPV1 has been shown to play a pivotal role in inflammation and immunity. Monocytes, macrophages, and dendritic cells express TRPV1, with both mouse and human studies suggesting that TRPV1 activation protects against endotoxin-induced inflammation. In contrast, TRPV1 (and other TRP channels) appears to be required for T-cell receptor activation by mitogens. Additionally, studies in cell lines derived from hematological and other malignancies suggest altered expression/function of TRPV1 might serve as a target for novel cytotoxic therapies.

Citations

Sep 12, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xenia KodjiSusan D Brain
Mar 22, 2019·Journal of Cellular Physiology·Enhui YaoXin Jin
Nov 27, 2018·Current Medicinal Chemistry·Joo Hyun Nam, Woo Kyung Kim
Jul 29, 2020·The Journal of Physiology·Wentong LongPeter E Light
Jan 30, 2019·Mediators of Inflammation·Fernando Erra DíazJorge Geffner
Dec 17, 2018·Molecular Biology Reports·Yan-Ruide Li, Puneet Gupta
Mar 9, 2021·Frontiers in Medicine·Aylin RuppensteinUlrike Raap
Feb 1, 2019·Molecular Pharmaceutics·Laura WeberDong Wang

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