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TRPV1 inhibition does not prevent cold dry air-elicited symptoms in non-allergic rhinitis

International Journal of Clinical Pharmacology and Therapeutics

Jan 30, 2014

Robert D MurdochDeepen Patel

Abstract

The transient receptor potential vanilloid 1 (TRPV1)-expressing sensory C-fibers may play a role in the development of nasal hyper-responsiveness and symptoms of non-allergic rhinitis (NAR). To evaluate the effects of a TRPV1-antagonist, SB-705498, on cold dry air (CDA)-induced symptoms...read more

Mentioned in this Paper

Biochemical Pathway
Neurologic Manifestations
Cold Temperature
Carmol
Antagonist Muscle Action
Pyrrolidines
N-(2-bromophenyl)-N'-((1-(5-trifluoromethyl-2-pyridyl)pyrrolidin-3-yl))urea
Vanilloid
SB 705498
Metabolic Inhibition
Paper Details
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TRPV1 inhibition does not prevent cold dry air-elicited symptoms in non-allergic rhinitis

International Journal of Clinical Pharmacology and Therapeutics

Jan 30, 2014

Robert D MurdochDeepen Patel

PMID: 24472402

DOI: 10.5414/cp202013

Abstract

The transient receptor potential vanilloid 1 (TRPV1)-expressing sensory C-fibers may play a role in the development of nasal hyper-responsiveness and symptoms of non-allergic rhinitis (NAR). To evaluate the effects of a TRPV1-antagonist, SB-705498, on cold dry air (CDA)-induced symptoms...read more

Mentioned in this Paper

Biochemical Pathway
Neurologic Manifestations
Cold Temperature
Carmol
Antagonist Muscle Action
Pyrrolidines
N-(2-bromophenyl)-N'-((1-(5-trifluoromethyl-2-pyridyl)pyrrolidin-3-yl))urea
Vanilloid
SB 705498
Metabolic Inhibition

Similar Papers Found In These Feeds

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.

Colon Adenocarcinoma

Approximately 95% of all colon cancers are colon adenocarcinomas, which are associated with a significant reduction in or loss of goblet cells. Here is the latest research on colon adenocarcinomas and its treatment.

Related Papers

International Journal of Clinical Pharmacology and Therapeutics

The effects of a TRPV1 antagonist, SB-705498, in the treatment of seasonal allergic rhinitis

International Journal of Clinical Pharmacology and TherapeuticsJune 6, 2013
Philippe BareilleFriedrich Horak
Paper Details
References
  • References
  • Citations6
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations6
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