TRPV4 activates autonomic and behavioural warmth-defence responses in Wistar rats

Acta Physiologica
R C L VizinM C Almeida

Abstract

In this study, we aimed at investigating the involvement of the warmth-sensitive channel - TRPV4 (in vitro sensitive to temperatures in the range of approx. 24-34 °C) - on the thermoregulatory mechanisms in rats. We treated rats with a chemical selective agonist (RN-1747) and two antagonists (RN-1734 and HC-067047) of the TRPV4 channel and measured core body temperature, metabolism, heat loss index and preferred ambient temperature. Our data revealed that chemical activation of TRPV4 channels by topical application of RN-1747 on the skin leads to hypothermia and this effect was blocked by the pre-treatment with the selective antagonist of this channel. Intracerebroventricular treatment with RN-1747 did not cause hypothermia, indicating that the observed response was indeed due to activation of TRPV4 channels in the periphery. Intravenous blockade of this channel with HC-067047 caused an increase in core body temperature at ambient temperature of 26 and 30 °C, but not at 22 and 32 °C. At 26 °C, HC-067047-induced hyperthermia was accompanied by increase in oxygen consumption (an index of thermogenesis), while chemical stimulation of TRPV4 increased tail heat loss, indicating that these two autonomic thermoeffectors in the rat are...Continue Reading

References

May 1, 1990·Physiology & Behavior·C J Gordon
Aug 5, 1998·The American Journal of Physiology·A A RomanovskyV A Kulchitsky
Jun 9, 2000·Annual Review of Neuroscience·J S MogilA I Basbaum
Jul 3, 2003·Nature Reviews. Neuroscience·Ardem PatapoutianVeena Viswanath
Aug 5, 2003·Neuron·Nicole Alessandri-HaberJon D Levine
Oct 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wolfgang Liedtke, Jeffrey M Friedman
Oct 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wolfgang LiedtkeJeffrey M Friedman
Mar 16, 2004·The European Journal of Neuroscience·Z SzelényiJ B Davis
Feb 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hyosang LeeMichael J Caterina
Mar 15, 2005·Neuroscience Letters·Tohko IidaMichael Caterina
Jun 14, 2005·Pflügers Archiv : European journal of physiology·Wolfgang Liedtke
Jan 13, 2006·Nature Chemical Biology·Thomas VoetsBernd Nilius
Jul 6, 2006·The European Journal of Neuroscience·Maria C AlmeidaAndrej A Romanovsky
Sep 5, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Kênia C BicegoLuiz G S Branco
Sep 16, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael J Caterina
Sep 26, 2006·Biochemical and Biophysical Research Communications·Thomas ChristophJens Kurreck
Sep 30, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrej A Romanovsky
Dec 22, 2006·PloS One·Maria C AlmeidaAndrej A Romanovsky
Jul 13, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexandre A SteinerAndrej A Romanovsky
Mar 17, 2009·Trends in Neurosciences·Julie A Kauer, Helen E Gibson
May 15, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicole Alessandri-HaberJon D Levine
Sep 10, 2009·Biochemical and Biophysical Research Communications·Fabien VincentMatthew A J Duncton
Oct 20, 2009·Progress in Biophysics and Molecular Biology·Wouter EveraertsGrzegorz Owsianik
Nov 3, 2009·Okajimas Folia Anatomica Japonica·Michiko Nakatsuka, Yasutomo Iwai
Feb 9, 2010·British Journal of Pharmacology·N VergnolleN W Bunnett
Oct 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·Wouter EveraertsThomas Voets
Jan 5, 2011·Frontiers in Bioscience (Landmark Edition)·Shaun F Morrison, Kazuhiro Nakamura
Jun 16, 2011·Current Topics in Medicinal Chemistry·Fabien Vincent, Matthew A J Duncton
Dec 21, 2011·Arthritis and Rheumatism·Alexandre Denadai-SouzaNicolas Cenac
Dec 31, 2011·Journal of Applied Physiology·Tatsuya KusudoHitoshi Yamashita
Feb 11, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·M Camila AlmeidaAndrej A Romanovsky
Jul 28, 2012·Expert Opinion on Therapeutic Patents·Antonio Ferrer-MontielRosario González-Muñiz
Nov 14, 2012·Molecular and Cellular Neurosciences·Gisela Segond von BanchetHans-Georg Schaible

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Citations

May 27, 2016·Temperature : Multidisciplinary Biomedical Journal·Maria Camila AlmeidaDaniel Carneiro Carrettiero
Jul 7, 2015·Cell Reports·Vincent J LynchStephan C Schuster
Feb 27, 2016·Acta Physiologica·Ralf Mrowka, Stefanie Reuter
Apr 5, 2017·Pflügers Archiv : European journal of physiology·Caroline Cristina-SilvaKênia C Bícego
Jun 3, 2016·Physiological Reviews·John P M WhiteIstvan Nagy
Feb 22, 2018·Journal of Clinical Neuromuscular Disease·Jacquie Baker, Kurt Kimpinski
Mar 28, 2018·Molecular Neurobiology·Hemant KumarInbo Han
Apr 19, 2018·Journal of Neurophysiology·John N BarrettSuhrud M Rajguru
Aug 21, 2019·Pflügers Archiv : European journal of physiology·Carolina da Silveira ScarpelliniKênia Cardoso Bícego
Oct 22, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Naoto FujiiTakeshi Nishiyasu
Jan 18, 2021·Journal of Thermal Biology·Robson Cristiano Lillo VizinMaria Camila Almeida
Feb 18, 2020·Bioorganic & Medicinal Chemistry Letters·Brian G LawhornDavid J Behm

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