PMID: 11327376May 1, 2001Paper

True hermaphroditism: clinical features, genetic variants and gonadal histology

Journal of Pediatric Endocrinology & Metabolism : JPEM
N YordamS Balci

Abstract

True hermaphroditism is a rare cause of intersexuality in which both ovarian and testicular tissue is present in the same individual. We present the clinical findings, karyotype, gonadal histology and management of eight patients with true hermaphroditism. Their ages ranged from 43 days to 12 years at the first evaluation. The presenting symptoms were ambiguous genitalia (6 patients), isolated clitoromegaly (1 patient) and hypospadias (1 patient). The most common karyotype was 46,XX (6 patients). In one patient the karyotype was 46,XY and in another 45,XO/46,XY mosaicism, which is rare in the literature. A vagina was found by genitography in all patients, and at laparotomy the uterus was found normal in five patients, hypoplastic in one patient, as a fibrous band in one, and absent in the remaining patient. Histological investigation of the gonads revealed bilateral ovotestis in two patients, ovotestis plus ovary in two patients, and ovary on one side and testis on the other side in three patients. Five patients were assigned to the female sex, and three to the male sex. One of these patients was changed from male to female after evaluation.

References

Jan 1, 1992·Hormone Research·R K LinskensH A Delemarre-van de Waal
May 1, 1987·The Journal of Urology·C F HeynsD P de Klerk
May 1, 1987·European Journal of Pediatrics·J Knudtzon, D Aarskog
Apr 1, 1984·Clinical Genetics·M C AyusoJ L Herrera
Jan 1, 1981·Human Genetics·W A van Niekerk, A E Retief
Apr 1, 1994·Urology·W A GourlayW R Nielsen
Jan 1, 1997·Acta Paediatrica·N Kandemir, N Yordam
Oct 20, 1998·Journal of Pediatric Endocrinology & Metabolism : JPEM·G Guerra JúniorA T Maciel-Guerra
Mar 21, 2000·Journal of Paediatrics and Child Health·A M WalkerC F Verge

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Citations

Aug 12, 2014·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Manuel NistalMiguel Reyes-Múgica
Aug 9, 2013·Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology·Kalum T WettasingheVajira H W Dissanayake
Apr 25, 2013·Journal of Pediatric Endocrinology & Metabolism : JPEM·Elif OzsuSukru Hatun

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