True risk of fetal/neonatal alloimmune thrombocytopenia in subsequent pregnancies: a prospective observational follow-up study

BJOG : an International Journal of Obstetrics and Gynaecology
Heidi TillerM Kjaer

Abstract

To assess neonatal platelet counts by comparing alloimmunised pregnancies from a Norwegian screening and intervention study with subsequent pregnancies from the same women. Prospective observational follow-up study. A university hospital. HPA-1a immunised women from a large Norwegian screening study that gave birth to one or more children after the screening study ended (2004-2012). Follow-up of maternal anti-HPA-1a antibody levels and neonatal platelet counts from the screening pregnancies were compared with subsequent pregnancies. None of the women received antenatal intravenous immunoglobulin (IVIG) treatment and neonatal platelet counts were therefore comparable. Change in neonatal platelet counts from one HPA-1a incompatible pregnancy to the next. Maternal anti-HPA-a1 antibody levels from one HPA-1a incompatible pregnancy to the next. Forty-five incompatible subsequent pregnancies were identified. Overall, the neonatal platelet count in the subsequent pregnancy was improved (18%), unchanged (52%), or worse (30%), compared with the corresponding screening pregnancy. There was one case of fetal intracranial haemorrhage (ICH) identified in the screening (intrauterine fetal death detected at 30 weeks of gestation) and no ICH c...Continue Reading

References

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Sep 8, 2012·Current Opinion in Hematology·Jens Kjeldsen-KraghBjørn Skogen

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Citations

Jun 11, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Sentot SantosoUlrich J Sachs
Mar 5, 2019·British Journal of Haematology·Lani LiebermanUNKNOWN International Collaboration for Transfusion Medicine Guidelines (ICTMG)
May 20, 2020·Journal of Clinical Medicine·Borros Arneth

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