PMID: 20630130Jul 16, 2010Paper

True vasculitis in lupus nephritis

Clinical Nephrology
A A AbdellatifL D Truong

Abstract

Vascular lesions are encountered frequently in renal biopsy specimens of patients with systemic lupus erythematosus (SLE) and can present in a variety of morphologic forms. True renal lupus vasculitis (TRLV) is one of the rare vascular lesions associated with lupus nephritis that has been infrequently reported in the medical literature. The primary focus on glomerular pathology and collective classification of the vascular lesions under lupus vasculopathy is one of the reasons why this form of inflammatory vasculitis has been under-recognized as a separate disease entity. Here we have comprehensively reviewed the literature on renal vascular involvement in SLE for a better understanding of the epidemiology, morphologic features, pathogenesis, clinical course and treatment of TRLV. It can be morphologically differentiated from other forms of renal vascular lesions in lupus nephritis, i.e. arteriosclerosis, uncomplicated vascular immune deposits, non-inflammatory necrotizing vasculopathy, and thrombotic microangiopathy. Despite close similarities with antineutrophil cytoplasmic autoantibody associated vasculitis (AASV), there are certain morphological differences that warrant a thorough investigation of the possible pauci-immune ...Continue Reading

Citations

Sep 18, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Chia-Ter ChaoJui-Tsung Ting
Apr 18, 2015·Journal of Forensic and Legal Medicine·Ann D TreacyMary N Sheppard
Aug 16, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Antonis IoannouGeorge C Tsokos
May 4, 2016·Clinical Rheumatology·David Herrera van OostdamCarlos Abud Mendoza
Feb 10, 2017·Lupus·J M Mejía-ViletL E Morales-Buenrostro
Feb 11, 2015·Lupus·B VaralaxmiV Siva Kumar
Oct 30, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Antonis IoannouGeorge C Tsokos
Feb 11, 2019·Néphrologie & thérapeutique·Quentin Raimbourg, Éric Daugas

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