Truths and myths about radiotherapy for verrucous carcinoma of larynx

International Journal of Radiation Oncology, Biology, Physics
Shao Hui HuangBrian O'Sullivan

Abstract

The role of primary radiotherapy (RT) for laryngeal verrucous carcinoma (LVC) is controversial because of concerns about anaplastic transformation, an increased incidence of metastases, and poorer local control after RT. To address these concerns, we report our experience. All patients with pathologically diagnosed LVC treated with primary RT at our institution between 1961 and 2004 were reviewed. The local control, overall survival, and disease-specific survival rate were established. The outcome after salvage treatment and the incidence of metastases and anaplastic transformation were determined. Of 62 LVC patients with a minimal follow-up of 2 years, 20 local and 1 nodal recurrence were identified. Salvage surgery was undertaken in 18 of the 21 patients, and disease control was achieved in 17; the eighteenth patient died of a complication after surgery. Ultimate laryngeal preservation was achieved in 50 patients (81%), including 42 after initial RT and an additional 8 after salvage surgery. Distant failure and anaplastic transformation were not observed. Second cancers after RT were identified in 4 patients, only 1 of which was a head-and-neck cancer detected 11 years later. Of the 39 deceased patients, only 3 died of LVC. T...Continue Reading

References

Aug 1, 1979·Journal of Neurology·G BauerE Rumpl
Dec 1, 1977·The Laryngoscope·R E RyanL H Weiland
Jul 1, 1976·The Annals of Otology, Rhinology, and Laryngology·H P BurnsD P Bryce
Apr 1, 1991·Clinical Otolaryngology and Allied Sciences·C A Milford, P E O'Flynn
Nov 1, 1985·Archives of Otolaryngology·A L AbramsonB Winkler
Jan 1, 1988·The Journal of Laryngology and Otology·A O Ibekwe, E Duvall
Oct 1, 1986·The Journal of Laryngology and Otology·P J HamlynH J Shaw
Aug 1, 1971·The Laryngoscope·H F BillerW C Bauer
Apr 1, 1980·The Laryngoscope·E MyersJ H Ogura
Apr 1, 1995·The Laryngoscope·M E Tharp, H Shidnia
Aug 1, 1996·The Journal of Laryngology and Otology·M López-AmadoT Labella-Caballero
Apr 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·O HansenA Berthelsen
Jan 1, 1997·Lasers in Surgery and Medicine·M DammG Arnold
May 7, 1998·Head & Neck·L J OrvidasV J Suman
May 14, 1998·The Journal of Laryngology and Otology·A FerlitoG M Mannarà
Jun 2, 1998·International Journal of Radiation Oncology, Biology, Physics·P WardeB J Cummings
Nov 1, 1963·American Journal of Surgery·P L GOETHALSK D DEVINE
Apr 22, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P StrojanM Auersperg
Sep 18, 2007·International Journal of Radiation Oncology, Biology, Physics·Sarada P ReddyBahman Emami

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Citations

May 27, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Mia E MillerAkira Ishiyama
Jun 1, 2014·Archives of Pathology & Laboratory Medicine·Akeesha A ShahEdward B Stelow
Dec 29, 2009·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Primoz StrojanAlessandra Rinaldo
Feb 3, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Kenneth O DevaneyLeon Barnes
Nov 26, 2010·Dental Clinics of North America·Easwar Natarajan, Ellen Eisenberg
Feb 6, 2017·Surgical Pathology Clinics·Lester D R Thompson
Jan 16, 2018·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Joshua FranklynJohn Muthusami
Aug 12, 2009·The Journal of Laryngology and Otology·J YiotakisL Manolopoulos
Jun 13, 2015·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Raeda Al-BannaiC Blake Gilks
Aug 28, 2020·Frontiers in Oncology·Thejus T JayakrishnanRodney E Wegner
Apr 2, 2017·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Fernando LópezAlfio Ferlito

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