Trying to improve compliance with prophylactic penicillin therapy in children with sickle cell disease

British Journal of Clinical Pharmacology
M BerkovitchN F Olivieri

Abstract

To evaluate compliance with prophylactic penicillin therapy in sickle cell disease (SCD) in children. Forty-five children aged 37 +/- 19 (9-84) months [mean +/- s.d; range] with homozygous SCD were recruited. After a baseline period of 2 months the patients were randomized to either the intervention or non-intervention group. The intervention consisted of a slide show explaining the pathogenesis of sickle cell disease and its complications; weekly phone calls by the clinic social worker; and a calendar. Compliance was again evaluated after the 2 month intervention period and after a further 2 month monitoring period without intervention. Compliance was monitored using the Medication Event Monitoring System. At the end of the 6 months, parents in both groups completed a questionnaire the aims of which were to determine knowledge and understanding of sickle cell disease and previous experience with infection. Patient admissions to the hospital during the study were recorded. Compliance during the 2 month baseline assessment was 66.0 +/- 32.5 (1.3-98.2)% and 69.3+25.4 (19.8-96.5)% in the intervention (n = 13) and non-intervention (n = 10) groups respectively (P = 0.79). During the next 2 months, compliance in the intervention grou...Continue Reading

References

Apr 27, 1991·BMJ : British Medical Journal·D CumminsS C Davies
Jul 1, 1990·Archives of Internal Medicine·J A CramerR H Mattson
Jun 19, 1986·The New England Journal of Medicine·M H GastonJ S Lobel
Jan 1, 1972·American Journal of Diseases of Children·R A SeelerM A Mufson
May 5, 1966·The New England Journal of Medicine·M G Robinson, R J Watson
Oct 9, 1993·Lancet·E C Wright

❮ Previous
Next ❯

Citations

Feb 1, 2003·Current Therapeutic Research, Clinical and Experimental·Keele E WurstThomas R Konrad
Oct 16, 1999·British Journal of Haematology·O Castro
Aug 28, 2009·Journal of Pediatric Psychology·Montserrat M GravesAmanda Boyer
Jan 27, 2012·Journal of Pediatric Hematology/oncology·Avani C ModiMonica J Mitchell
May 24, 2011·Advances in Urology·Esequiel RodriguezHillary L Copp
Mar 6, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Christine B SiebergShashi Seshia
Dec 24, 2013·Journal of Infection and Public Health·Shiow-Huey ChangMaria Lourdes U Finelli
Jul 5, 2011·The Journal of Pediatrics·Lisa M IngerskiKevin A Hommel
Nov 3, 2009·The Journal of Pediatrics·Courtney D ThornburgAlex R Kemper
Sep 11, 2007·Infectious Disease Clinics of North America·Victoria E PriceE Lee Ford-Jones
Sep 20, 2015·Journal of Pediatric Psychology·Kristin LoiselleAhna L H Pai
Jun 6, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Catherine BoothStephen K Obaro
Jan 10, 2001·The Journal of Pediatrics·J Knight-Madden, G R Serjeant
Oct 12, 2007·Paediatric Drugs·Doreen Matsui
Mar 21, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Amanda J DriscollDavid R Murdoch
Oct 11, 2017·The Cochrane Database of Systematic Reviews·Angela E Rankine-Mullings, Shirley Owusu-Ofori
May 18, 2020·Journal of Pediatric Psychology·Sharon Shih, Lindsey L Cohen
Mar 17, 2021·The Cochrane Database of Systematic Reviews·Angela E Rankine-Mullings, Shirley Owusu-Ofori
Jun 23, 2019·Pediatrics·David C BrousseauStaci Arnold

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.