Trypanocidal and cytotoxic effects of 30 Ethiopian medicinal plants

Zeitschrift Für Naturforschung. C, a Journal of Biosciences
E Nibret, Michael Wink

Abstract

Trypanocidal and cytotoxic effects of traditionally used medicinal plants of Ethiopia were evaluated. A total of 60 crude plant extracts were prepared from 30 plant species using CH2Cl2 and MeOH. Effect upon cell proliferation by the extracts, for both bloodstream forms of Trypanosoma brucei brucei and human leukaemia HL-60 cells, was assessed using resazurin as vital stain. Of all CH2Cl2 and MeOH extracts evaluated against the trypanosomes, the CH2Cl2 extracts from five plants showed trypanocidal activity with an IC50 value below 20 microg/mL: Dovyalis abyssinica (Flacourtiaceae), IC50 = 1.4 microg/mL; Albizia schimperiana (Fabaceae), IC50 = 7.2 microg/mL; Ocimum urticifolium (Lamiaceae), IC50 = 14.0 microg/mL; Acokanthera schimperi (Apocynaceae), IC50 = 16.6 microg/mL; and Chenopodium ambrosioides (Chenopodiaceae), IC50 = 17.1 microg/mL. A pronounced and selective killing of trypanosomes with minimal toxic effect on human cells was exhibited by Dovyalis abyssinica (CH2Cl2 extract, SI = 125.0; MeOH extract, SI = 57.7) followed by Albizia schimperiana (CH2Cl2 extract, SI = 31.3) and Ocimum urticifolium (MeOH extract, SI = 16.0). In conclusion, the screening of 30 Ethiopian medicinal plants identified three species with good ant...Continue Reading

Citations

Jun 4, 2014·Journal of Medicinal Food·Marcel Gianni C da SilvaBenito Soto-Blanco
Jan 2, 2016·Journal of Ethnopharmacology·Leonidah K OmosaThomas Efferth
May 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Solomon TesfayeKaleab Asres
Mar 24, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohamed A O AbdelfattahMansour Sobeh
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Solomon TesfayePatrick J Bednarski
Sep 15, 2021·Natural Product Research·Mohamed A A OrabiKatsuyoshi Matsunami

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