PMID: 45125Jan 1, 1979

Trypanosoma brucei infection in nude mice: B lymphocyte function is suppressed in the absence of T lymphocytes

Parasite Immunology
C E ClaytonB A Askonas

Abstract

B lymphocyte function was assessed in outbred nude mice and nu/+controls infected with Trypanosoma brucei brucei. On day 10 of the infection in outbred nu/nu mice in which the initial wave of parasites was strongly controlled, B cell function was unaltered on enhanced compared with uninfected animals or infected nu/+. In other nu/nu mice unable to control the initial parasitaemia, thymidine incorporation and Ig secretion by spleen cells were increased on day 10 and their response to lipopolysaccharide in vitro negated. By day 15 however, even the spleen cells of infected nu/nu which controlled the initial wave of parasites were proliferating and secreting Ig on removal from the mice and they were unable to respond to LPS in vitro. These experiments confirm results of a previous study of B cell function in T cell-depleted mice (Askonas et al. 1979). T. b. brucei infection of mice causes both enhanced Ig production and suppression of the ability of B cells to respond to mitogen even in the absence of T cells, but the presence of T cells may accelerate the changes which occur in B lymphocytes following this infection.

References

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Citations

Jan 1, 1976·Infection·M Majer
Oct 1, 1978·European Journal of Immunology·T W PearsonK S Mayor-Withey
Feb 10, 1977·Nature·A N Jayawardena, B H Waksman
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·B A Askonas, J R North
Jun 1, 1978·Infection and Immunity·G H CampbellS M Phillips
Jan 15, 1978·Experientia·R K Assoku, I R Tizard
Jan 1, 1978·Infection·H G de Vries-Hospers, D van der Waaij
Jun 1, 1976·Annals of Tropical Medicine and Parasitology·A G Luckins
Jan 1, 1973·Transactions of the Royal Society of Tropical Medicine and Hygiene·B M GreenwoodD H Molyneux

Related Concepts

Mice, Inbred CBA
T-Lymphocyte
Thymidine
Spleen
House mice
Process of Secretion
Immunoglobulins
B-Lymphocytes
Visual Suppression
Cell Division Phases

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