Trypanosoma cruzi adjuvants potentiate T cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine

PloS One
Caroline JunqueiraRicardo T Gazzinelli

Abstract

Immunological adjuvants that induce T cell-mediate immunity (TCMI) with the least side effects are needed for the development of human vaccines. Glycoinositolphospholipids (GIPL) and CpGs oligodeoxynucleotides (CpG ODNs) derived from the protozoa parasite Trypanosoma cruzi induce potent pro-inflammatory reaction through activation of Toll-Like Receptor (TLR)4 and TLR9, respectively. Here, using mouse models, we tested the T. cruzi derived TLR agonists as immunological adjuvants in an antitumor vaccine. For comparison, we used well-established TLR agonists, such as the bacterial derived monophosphoryl lipid A (MPL), lipopeptide (Pam3Cys), and CpG ODN. All tested TLR agonists were comparable to induce antibody responses, whereas significant differences were noticed in their ability to elicit CD4(+) T and CD8(+) T cell responses. In particular, both GIPLs (GTH, and GY) and CpG ODNs (B344, B297 and B128) derived from T. cruzi elicited interferon-gamma (IFN-γ) production by CD4(+) T cells. On the other hand, the parasite derived CpG ODNs, but not GIPLs, elicited a potent IFN-γ response by CD8(+) T lymphocytes. The side effects were also evaluated by local pain (hypernociception). The intensity of hypernociception induced by vaccinat...Continue Reading

References

Dec 1, 1976·The Journal of Infectious Diseases·D M WilliamsJ S Remington
Sep 14, 1990·Journal of Immunological Methods·Y Aida, M J Pabst
Sep 16, 1985·European Journal of Biochemistry·R M de LederkremerW Colli
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T L KipnisW D da Silva
Jan 1, 1983·Annals of the New York Academy of Sciences·R N Taylor, K M Fulford
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R A SederWilliam E Paul
Nov 24, 1999·The Journal of Biological Chemistry·Egil LienDouglas T Golenbock
Dec 22, 1999·Immunogenetics·H RammenseeStefan Stevanovic
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marco A CamposRicardo T Gazzinelli
Oct 31, 2002·Nature Immunology·Gavin P DunnRobert D Schreiber
Nov 26, 2002·Immunological Reviews·Matthew J ScanlanYao-Tseng Chen
Nov 26, 2002·Immunological Reviews·Cornelis J M MeliefRienk Offringa
Feb 4, 2003·Nature Reviews. Immunology·Giorgio Trinchieri
Feb 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Carlos Amilcar ParadaS H Ferreira
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marco A CamposRicardo T Gazzinelli
Feb 11, 2004·American Journal of Epidemiology·Francesmary Modugno
Apr 3, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T M CunhaS H Ferreira
Apr 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eugene MaraskovskyAndreas Suhrbier
Oct 21, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ana-Carolina OliveiraMaria Bellio
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·John J DonnellyMargaret A Liu
Jun 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karen ZaksSteven Dow
Jun 24, 2006·The Journal of Clinical Investigation·Hiroyoshi NishikawaSacha Gnjatic
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andre BaficaAlan Sher
Nov 18, 2006·Nature Reviews. Immunology·Ricardo T Gazzinelli, Eric Y Denkers
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Danila ValmoriMaha Ayyoub
Jul 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniella C BartholomeuRicardo T Gazzinelli
Sep 25, 2008·Paediatric Anaesthesia·Brian J Anderson
Dec 5, 2008·Nature Reviews. Cancer·Seth Rakoff-Nahoum, Ruslan Medzhitov
Mar 12, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sacha GnjaticPadmanee Sharma

Citations

Sep 8, 2015·Vaccines·Hidekazu ShirotaDennis M Klinman
Jul 3, 2013·International Journal of Oncology·Verónica NoyaTeresa Freire
Nov 1, 2015·International Journal of Cancer. Journal International Du Cancer·Luis UbillosEduardo Osinaga
Sep 2, 2016·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Motoya Mie, Takeshi Takahashi

Methods Mentioned

BETA
nuclear magnetic resonance
flow cytometry
ELISA
enzyme-linked immunosorbent assay
dot blots

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