Trypanosoma cruzi: alteration in the lymphoid compartments following interruption of infection by early acute benznidazole therapy in mice

Experimental Parasitology
Bianca P OlivieriTânia C de Araújo-Jorge

Abstract

Disability and mortality as consequence of Chagas disease is enormous in South America. Recently, the success of the trypanocidal treatment with benznidazole, the only available drug, has been associated with the host immune response. In the current study, the impact of benznidazole administration immediately after the experimental infection with Trypanosoma cruzi was evaluated in the main lymphocyte populations in lymphoid organs. Untreated mice displayed enlargement of spleen and lymph node related to the increased frequency of T and B lymphocytes, respectively. An intense thymus involution with the depletion of CD4(+)CD8(+) double-positive thymocytes also occurred. Benznidazole treatment led to a partial reversion of the spleen and lymph node enlargement related to changes in the frequency of lymphocyte subsets due to infection. Prevention of thymus involution was achieved, with the profile of thymocyte subsets similar to that of non-infected mice. The parasitic load at the onset of T. cruzi infection seems critical to trigger immune system activation.

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Citations

Dec 29, 2007·Parasitology Research·Gabriel Melo de OliveiraAndréa Pereira de Souza
Sep 16, 2008·Experimental Parasitology·Amanda Fortes FranciscoCláudia Martins Carneiro
Sep 17, 2016·Asian Pacific Journal of Tropical Medicine·Áurea Regina Telles PupulinCiomar Aparecida Bersani-Amado
May 21, 2015·Memórias do Instituto Oswaldo Cruz·María Cecilia Albareda, Susana Adriana Laucella
Feb 9, 2017·Antimicrobial Agents and Chemotherapy·Luísa PerinCláudia Martins Carneiro
Jun 17, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Mónica C GarcíaMaria P Aoki

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