Trypanosoma-Cruzi Cross-Reactive Antibodies Longitudinal Follow-Up: A Prospective Observational Study in Hematopoietic Stem Cell Transplantation

PloS One
Esber S SabaMaan A Zrein

Abstract

Antibodies named TcCRA "Trypanosoma cruzi Cross Reactive Antibodies" were detected in 47% of blood donors from French population unexposed to the parasite. In order to evaluate the passive or active transmissibility of TcCRA and further characterize its role and etiology, we have conducted a study in a cohort of 47 patients who underwent allogeneic Hematopoietic Stem Cell Transplantations (allo-HSCT). Donors and recipients were tested for TcCRA prior to transplantation. Recipients were further tested during follow-up after transplantation. Demographical, clinical and biological data were collected. Our primary end-point was to assess the risk of TcCRA acquisition after transplantation. During this initial analysis, we observed no seroconversion in patients receiving cells from TcCRA negative donors (n = 23) but detected seroconversion in 4 out of 24 patients who received hematopoietic stem cells from positive donors. Here, we are discussing possible scenarios to explain TcCRA-immune status in recipient after transplantation.

References

Apr 17, 2001·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·D AviganH M Lazarus
Jun 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C A DykewiczUNKNOWN American Society of Blood and Marrow Transplantation
Jun 22, 2005·Bone Marrow Transplantation·S S NeelapuL W Kwak
Mar 14, 2009·Lancet·James L M FerraraErnst Holler
Apr 21, 2012·Current Opinion in Hematology·Mark BoschJan Storek
Jul 4, 2013·The Journal of Infectious Diseases·Nikolay PopgeorgievChristelle Desnues
Nov 5, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Nikolay PopgeorgievChristelle Desnues

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