Trypanosoma cruzi, etiological agent of Chagas disease, is virulent to its triatomine vector Rhodnius prolixus in a temperature-dependent manner

PLoS Neglected Tropical Diseases
Simon L ElliotAlessandra A Guarneri

Abstract

It is often assumed that parasites are not virulent to their vectors. Nevertheless, parasites commonly exploit their vectors (nutritionally for example) so these can be considered a form of host. Trypanosoma cruzi, a protozoan found in mammals and triatomine bugs in the Americas, is the etiological agent of Chagas disease that affects man and domestic animals. While it has long been considered avirulent to its vectors, a few reports have indicated that it can affect triatomine fecundity. We tested whether infection imposed a temperature-dependent cost on triatomine fitness. We held infected insects at four temperatures between 21 and 30°C and measured T. cruzi growth in vitro at the same temperatures in parallel. Trypanosoma cruzi infection caused a considerable delay in the time the insects took to moult (against a background effect of temperature accelerating moult irrespective of infection status). Trypanosoma cruzi also reduced the insects' survival, but only at the intermediate temperatures of 24 and 27°C (against a background of increased mortality with increasing temperatures). Meanwhile, in vitro growth of T. cruzi increased with temperature. Our results demonstrate virulence of a protozoan agent of human disease to its...Continue Reading

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Citations

Aug 21, 2015·PLoS Neglected Tropical Diseases·Newmar Pinto MarliéreAlessandra Aparecida Guarneri
Jun 28, 2017·Parasitology·Anna Cláudia Guimarães FreireCarlos Renato Machado
Jan 29, 2016·Parasitology·Roberta Carvalho FerreiraAlessandra Aparecida Guarneri
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May 18, 2019·Parasites & Vectors·Guiehdani VillalobosAlex Córdoba-Aguilar
Feb 12, 2021·PLoS Neglected Tropical Diseases·Sabrina Clavijo-BaquetFrancisco Bozinovic
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Jul 2, 2021·PLoS Neglected Tropical Diseases·Newmar Pinto MarliéreAlessandra Aparecida Guarneri
Aug 6, 2021·Parasites & Vectors·Berenice González-ReteAlex Córdoba-Aguilar

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Methods Mentioned

BETA
transgenic
flow cytometry
using flow cytometry

Software Mentioned

R
FlowJo

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