Trypanosoma cruzi III causing the indeterminate form of Chagas disease in a semi-arid region of Brazil

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Kiev MartinsAntonia Cláudia Jácome da Câmara

Abstract

Trypanosoma cruzi is subdivided into six discrete typing units (DTUs), TcI-TcVI. The precise identification of each can contribute to tracking wild DTUs that invade the domiciliary environment. Twenty T. cruzi stocks isolated from 16 chagasic patients, two Panstrongylus lutzi, one Galea spixii, and one Euphractus sexcinctus, from different localities in the State of Rio Grande do Norte, Brazil, were characterized by genotyping the 3' region of the 24Sα rRNA gene, the mitochondrial cytochrome oxidase subunit 2 gene, and the spliced leader intergenic region. TcIII was identified in 18.7% (3/16) of patients from different municipalities, as well as in P. lutzi, G. spixii, and E. sexcinctus, indicating the connection between the sylvatic and domestic cycles in this Brazilian semi-arid region. TcI and TcII were also detected, in 37.5% (6/16) and 43.8% (7/16) of patients, respectively. These DTUs were associated with cardiac, digestive, and indeterminate clinical forms, while TcIII was identified only in patients with the indeterminate form. The occurrence of these DTUs reveals important phylogenetic diversity in T. cruzi isolates from humans. TcIII is reported for the first time in northeastern Brazil. These findings appear to indic...Continue Reading

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Citations

May 22, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Iván A BontempiCristina Diez
Mar 23, 2017·Revista Da Sociedade Brasileira De Medicina Tropical·Tatiana da Silva Fonseca de OliveiraMaria Auxiliadora de Sousa
May 11, 2016·Revista Da Sociedade Brasileira De Medicina Tropical·Andressa Noronha Barbosa-SilvaLúcia Maria da Cunha Galvão
Nov 15, 2018·The American Journal of Tropical Medicine and Hygiene·Simone Caldas TevesTeresa Cristina Monte Gonçalves
Nov 27, 2018·Parasite : Journal De La Société Française De Parasitologie·Maria Augusta DarioAloísio Falqueto
Oct 9, 2018·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Natalia Paula MacchiavernaMarta Victoria Cardinal
May 13, 2021·Acta Tropica·Nathan Ravi Medeiros HonoratoAntônia Cláudia Jácome da Câmara
Aug 3, 2021·Frontiers in Cellular and Infection Microbiology·Tamyres Bernadete Dantas QueirogaPaulo Marcos Matta Guedes
Jul 1, 2019·Acta Tropica·Vicente Toscano de Araújo-NetoAntonia Claudia Jácome da Câmara

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