Trypanosoma cruzi: maintenance of parasite-specific T cell responses in lymph nodes during the acute phase of the infection

Experimental Parasitology
M A Curotto de LafailleI A Abrahamsohn

Abstract

Mice infected with 5 x 10(3) forms of Trypanosoma cruzi showed a transient, but severe impairment of in vitro spleen cell responses to parasite antigens and to Concanavalin A (Con A). In contrast, inguinal and periaortic lymph node (LN) cells displayed high parasite-specific proliferative responses and only a partial reduction of the Con A-induced proliferation during the acute and chronic phases of infection. Lymphocytes that underwent blastic transformation in T. cruzi-stimulated cell cultures were of the L3T4+ phenotype. Suppression of spleen cell responses occurred in the acute phase whether mice were infected with high (3 x 10(5] or low (5 x 10(3] doses of T. cruzi by intraperitoneal or subcutaneous route. Suppression of the T. cruzi-specific proliferative response of LN cells was only observed in mice infected with high subcutaneous inocula. This suppression, however, was restricted to the LNs draining the site of inoculation without affecting distant LNs. Supernatants from parasite-stimulated proliferating LN cells displayed low or undetectable T cell growth factor (TCGF) activity, in contrast with the high TCGF levels found in supernatants of the same cells stimulated with Con A. Low levels of TCGF were also detected in...Continue Reading

References

Aug 1, 1978·Experimental Parasitology·C RamosL Ortiz-Ortiz
Jun 1, 1975·Experimental Parasitology·B A ClintonR Capin
Dec 1, 1986·Scandinavian Journal of Immunology·P M MinoprioH Eisen
Mar 1, 1987·Parasite Immunology·S P NickellG A Cole
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A Harel-BellanH Eisen
Mar 1, 1984·Revista Do Instituto De Medicina Tropical De São Paulo·J A O'DalyH Caballero
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J J SandoJ J Farrar

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Citations

Apr 20, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sílvia de Barros-MazonIses A Abrahamsohn
Nov 28, 2001·Immunology·A P Galvão da Silva, I de Almeida Abrahamsohn
Mar 18, 2000·Infection and Immunity·I A AbrahamsohnR L Coffman
Oct 1, 1991·Experimental Parasitology·I J CamargoH A Rangel
Aug 25, 2004·Journal of Autoimmunity·Carlos E TadokoroIses A Abrahamsohn
Aug 1, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·I A Abrahamsohn
Nov 26, 2003·Immunology and Cell Biology·Jacqueline F JacysynMahasti S Macedo
Sep 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·U MüllerC Hölscher
Aug 25, 2009·Experimental Parasitology·Ana Claudia Henriques PintoJosé Clóvis do Prado

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