Trypanosoma cruzi-specific immune responses in subjects from endemic areas of Chagas disease of Argentina.

Microbes and Infection
Gabriela Carina OliveraM Postan

Abstract

Trypanosoma cruzi-specific immune responses were evaluated in a total of 88 subjects living in areas endemic of Chagas disease of Argentina by IFN-gamma ELISPOT assays and immunoblotting. Positive T. cruzi antigen-induced IFN-gamma responses were detected in 42% of subjects evaluated (15/26 positive by conventional serology and 22/62 seronegative subjects). Using immunoblotting, T. cruzi-specific IgG reactivity was detected in all seropositive subjects and in 11% (7/61) of subjects negative by conventional serology. Measurements of T cell responses and antibodies by immunoblotting, in conjunction with conventional serology, might enhance the capability of detection of exposure to T. cruzi in endemic areas.

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Citations

Apr 8, 2017·Expert Review of Cardiovascular Therapy·Yelenca Ortega ZamoraFredy R S Gutierrez
Apr 9, 2014·The American Journal of Tropical Medicine and Hygiene·Diana L MartinCaryn Bern
Sep 30, 2017·Cells·Josué da Costa Lima-JuniorFátima Conceição-Silva
Mar 5, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jose MateusAdriana Cuéllar

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