Abstract
There is evidence that autoimmune aberrations may contribute to the immunopathological consequences of Chagas' disease and because of this we sought to determine whether four inbred strains of mice bearing the single autosomal recessive gene, lpr (lymphoproliferation), which controls certain autoimmune manifestations, are particularly susceptible to acute infection with the Y strain of Trypanosoma cruzi. MRL/MpJ-lpr/lpr, C57Bl/6J-lpr/lpr, AKR/J-lpr/lpr, C3H/HeJ-lpr/lpr showed parasitaemias 2-10 times higher when compared to their congenic partners. Mortality was significantly higher in three of the four lpr strains. The results indicate that a single autosomal recessive gene which is associated with autoimmunity can influence susceptibility to acute T. cruzi infection in mice.
References
Aug 1, 1978·Experimental Parasitology·T TrischmannB Bloom
Nov 1, 1978·The Journal of Experimental Medicine·B S AndrewsF J Dixon
Nov 1, 1979·Arthritis and Rheumatism·E D Murphy, J B Roths
Aug 30, 1980·Lancet·G H Tovey
Jan 1, 1980·Advances in Parasitology·Z Brener
Mar 4, 1982·Nature·J N WoodM Yamamoto
Mar 1, 1980·Clinical Immunology and Immunopathology·A N TheofilopoulosW D Creighton
Feb 1, 1980·Parasitology·I A Abrahamsohn, J K Kloetzel
Jun 1, 1981·Experimental Parasitology·N NogueiraZ Cohn
Oct 1, 1981·Experimental Parasitology·H B TanowitzM Wittner
Jan 1, 1981·Parasite Immunology·M T Scott
Nov 1, 1980·The Journal of Experimental Medicine·D S PisetskyD V Peters
Citations
Oct 6, 2001·Trends in Parasitology·C G LüderM F Lopes
May 31, 2001·Immunology·G A MartinsJ S Silva
Mar 23, 2012·Journal of Virology·Mina O SeedhomRaymond M Welsh
Jun 1, 1985·The Journal of Clinical Investigation·W F PiessensL L Laughlin
Feb 20, 2014·PLoS Neglected Tropical Diseases·Vasco RodriguesJérôme Estaquier
Dec 1, 1986·Experimental Parasitology·S P Nickell, M H Boyer
Jul 1, 1985·Parasite Immunology·S P NickellM H Boyer
Jan 31, 2007·Journal of Leukocyte Biology·Landi V Costilla GuillermoMarcela F Lopes
Oct 5, 2006·Parasitology·F SchaumburgC G K Lüder
Jan 1, 1987·Immunogenetics·E Lamoyi, R Mage
Nov 13, 1984·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·L Hudson
Apr 1, 1987·Revista Da Sociedade Brasileira De Medicina Tropical·A R TeixeiraL V Rizzo
Jul 23, 1999·Infection and Immunity·G A MartinsJ S Silva
Dec 11, 2020·Microbial Pathogenesis·Supriya Rajendra RananawareDipankar Nandi
Dec 1, 1984·Infection and Immunity·T M Trischmann