Trypanosomatid histones

Molecular Microbiology
Sam Alsford, David Horn

Abstract

The histones are responsible for packaging and regulating access to eukaryotic genomes. Trypanosomatids are flagellated protists that diverged early from the eukaryotic lineage and include parasites that cause disease in humans and other mammals. Here, we review the properties of histones in parasitic trypanosomatids, from gene organization and sequence to expression, post-translational modification and function within chromatin. Phylogenetic and experimental analysis indicates that certain specifically conserved histone sequence motifs, particularly within the N-terminal 'tail' domains, possibly represent functionally important modification substrates conserved throughout the eukaryotic lineage. For example, histone H3 contains a highly conserved methylation substrate. Trypanosomatids also possess at least three variant histones. Among these is an orthologue of H2A.Z, a histone involved in protecting 'active' chromatin from silencing in yeast. Histones provide docking platforms for a variety of regulatory factors. The presence of histone modification and variant histones in trypanosomatids therefore represents evidence for a network that provides the discrimination required to regulate transcription, recombination, repair and ...Continue Reading

References

Mar 1, 1992·Trends in Biochemical Sciences·S Y Roth, C D Allis
Jun 1, 1994·Molecular and Biochemical Parasitology·L AslundU Pettersson
Jan 25, 1994·Nucleic Acids Research·T H Thatcher, M A Gorovsky
Aug 1, 1993·Journal of Cellular Biochemistry·G C ToroC Wernstedt
Apr 10, 1996·Experimental Cell Research·I EspinozaN Galanti
Feb 1, 1997·Molecular and Biochemical Parasitology·T M NollN J Fasel
Feb 26, 1998·Molecular and Biochemical Parasitology·M SotoJ M Requena
May 11, 1999·Parasitology Today·K ErsfeldK Gull
Sep 22, 1999·European Journal of Biochemistry·J A García-SalcedoE Pays
Mar 1, 2000·Trends in Biochemical Sciences·H H Ng, A Bird
Apr 14, 2000·Archives of Microbiology·K Sandman, J N Reeve
Nov 4, 2000·The Journal of Biological Chemistry·A GunjanD T Brown
Nov 23, 2000·Molecular and Biochemical Parasitology·D J LaCountJ E Donelson
Dec 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·D Shore
Feb 13, 2001·Journal of Cellular Biochemistry·V SabajN Galanti
Apr 11, 2001·Molecular and Biochemical Parasitology·R F RecinosJ E Donelson
Jun 8, 2001·Annual Review of Biochemistry·S Y RothC D Allis
Aug 22, 2001·International Journal for Parasitology·D Horn
Jan 30, 2002·Molecular and Biochemical Parasitology·Rafael Marques PortoSergio Schenkman
Jun 18, 2002·Current Opinion in Cell Biology·Monika Lachner, Thomas Jenuwein
Jul 27, 2002·Trends in Genetics : TIG·Asad U Khan, Michael Hampsey
Aug 2, 2002·Nature·Scott D BriggsBrian D Strahl
Sep 28, 2002·Nature·Helena Santos-RosaTony Kouzarides
Dec 11, 2002·Current Opinion in Cell Biology·William F Marzluff, Robert J Duronio
Mar 12, 2003·Cell·Fred van Leeuwen, Daniel E Gottschling
Apr 4, 2003·Current Opinion in Genetics & Development·Barbara G Mellone, Robin C Allshire
Apr 5, 2003·Annual Review of Biochemistry·Laura N RuscheJasper Rine

❮ Previous
Next ❯

Citations

May 30, 2012·Expert Reviews in Molecular Medicine·Sam AlsfordMark C Field
Jun 17, 2009·Nature Reviews. Microbiology·Luisa M FigueiredoChristian J Janzen
May 3, 2013·Open Biology·Bungo Akiyoshi, Keith Gull
Jul 23, 2015·International Journal for Parasitology. Drugs and Drug Resistance·Jessica A EngelKatherine T Andrews
May 8, 2007·Trends in Microbiology·Miguel NavarroDavid Landeira
Apr 17, 2007·Trends in Parasitology·David Horn
Jan 9, 2007·Experimental Parasitology·Slavica MasinaNicolas Fasel
Oct 10, 2006·Cellular Microbiology·William J SullivanSergio O Angel
Nov 2, 2006·Molecular Microbiology·Catherine J Merrick, Manoj T Duraisingh
Jan 23, 2013·Cellular Microbiology·Nilmar Silvio Moretti, Sergio Schenkman
Mar 12, 2011·Research in Microbiology·Klaus Ersfeld
Mar 6, 2007·Molecular and Biochemical Parasitology·Tansy C Hammarton
Feb 23, 2012·Molecular and Biochemical Parasitology·Lucy Glover, David Horn
Oct 3, 2006·Molecular and Biochemical Parasitology·Julia Pinheiro Chagas da CunhaSergio Schenkman
Aug 15, 2012·FEMS Microbiology Letters·Anup Kumar Maity, Partha Saha
Jan 13, 2017·Journal of Proteome Research·Gisele F A PicchiLyris M F de Godoy
Nov 18, 2016·Molecular & Cellular Proteomics : MCP·Teresa Cristina Leandro de JesusJulia Pinheiro Chagas da Cunha
Jan 13, 2017·Microbiology and Molecular Biology Reviews : MMBR·Victoria JeffersWilliam J Sullivan
Apr 13, 2005·The Journal of Biological Chemistry·Victoria L MarshStephen D Bell
Dec 4, 2012·Expert Review of Anti-infective Therapy·Laura VanagasSergio O Angel
May 30, 2020·PLoS Neglected Tropical Diseases·Rubens Daniel Miserani MagalhãesMaria Júlia Manso Alves
Oct 3, 2018·Future Science OA·Aline A Zuma, Wanderley de Souza
Nov 1, 2020·Trends in Parasitology·Anzhelika ButenkoJulius Lukeš
Jan 27, 2021·PLoS Pathogens·Alex R J LimaJulia P C da Cunha
Mar 24, 2020·Analytica Chimica Acta·Valerio FrezzaVíctor M González
Nov 24, 2005·Journal of Cell Science·Joanna E LowellGeorge A M Cross
Jun 19, 2021·European Journal of Protistology·Jean de Oliveira SantosMaria Cristina M Motta
Apr 26, 2016·Journal of Proteome Research·Teresa Cristina Leandro de JesusJulia Pinheiro Chagas da Cunha
May 7, 2009·Genes & Development·Paul B Talbert, Steven Henikoff

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