PMID: 8995788Jul 1, 1996Paper

Trypsin and aminopeptidase gene expression is affected by age and food composition in Anopheles gambiae

Insect Biochemistry and Molecular Biology
Francisco J A LemosM Jacobs-Lorena

Abstract

The effects of age and food composition on the expression of trypsin and aminopeptidase genes in the Anopheles gambiae gut were investigated. No trypsin mRNA was detected in the gut of newly eclosed females, but this mRNA accumulated to relatively high levels within the first day of life. In contrast, low, but significant trypsin enzyme activity was observed in newly eclosed females. Subcellular fractionation experiments suggested that abdominal distention induces the secretion of the enzyme into the lumen. Blood, but not a protein-free meal, induced the accumulation of new trypsin mRNA and enzyme. Unlike trypsin, substantial aminopeptidase activity was detected in newly eclosed and in older, sugar fed mosquitoes. Moreover, the subcellular localization of aminopeptidase did not change appreciably with food ingestion, and the early increase of enzyme activity was independent of food composition.

References

Sep 1, 1975·Journal of Insect Physiology·H Briegel, A O Lea
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M Church, W Gilbert
Jun 1, 1994·Insect Biochemistry and Molecular Biology·F G NoriegaM A Wells
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·B Xiong, M Jacobs-Lorena
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May 1, 1983·Wilhelm Roux's Archives of Developmental Biology·Alanna Ruddell, Marcelo Jacobs-Lorena

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Citations

May 29, 2003·Journal of Insect Physiology·F G. NoriegaM A. Wells
Jan 22, 2003·Insect Biochemistry and Molecular Biology·J M Ramalho-OrtigãoJ G Valenzuela
Aug 14, 2003·Insect Biochemistry and Molecular Biology·José M C Ribeiro
May 7, 1998·Insect Biochemistry and Molecular Biology·M J EdwardsM Jacobs-Lorena
Jan 15, 1999·Insect Biochemistry and Molecular Biology·Z Shen, M Jacobs-Lorena
Feb 15, 2000·Insect Molecular Biology·M J EdwardsM Jacobs-Lorena
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·L A MoreiraM Jacobs-Lorena
Aug 4, 2007·Proceedings of the National Academy of Sciences of the United States of America·Rhoel R DinglasanMarcelo Jacobs-Lorena
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·Z ShenM Jacobs-Lorena
Feb 10, 2004·Journal of Medical Entomology·A S CarociO Marinotti
Nov 29, 2008·Insect Biochemistry and Molecular Biology·R R DinglasanM Jacobs-Lorena
Mar 31, 2005·Insect Molecular Biology·C LavazecC Bourgouin
Apr 29, 2005·Insect Biochemistry and Molecular Biology·Nobutaka KatoBruce M Christensen
Oct 2, 2015·Malaria Journal·Romain PigeaultAna Rivero
May 30, 2015·Parasites & Vectors·Geovane Dias-LopesJose Batista De Jesus
Aug 13, 2015·Pesticide Biochemistry and Physiology·Rahul K SuryawanshiSatish V Patil
Jun 21, 2001·Genesis : the Journal of Genetics and Development·A M FontesM Jacobs-Lorena
May 25, 2002·Nature·Junitsu ItoMarcelo Jacobs-Lorena
Nov 20, 1997·The Journal of Biological Chemistry·Z Shen, M Jacobs-Lorena
Feb 18, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C F CurtisI Kasumba
Aug 9, 2002·The Journal of Biological Chemistry·Luciano A MoreiraMarcelo Jacobs-Lorena
Aug 20, 2005·The Journal of Experimental Biology·Maria del Pilar CorenaPaul J Linser

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