Trypsin inhibitor from tamarindus indica L. seeds reduces weight gain and food consumption and increases plasmatic cholecystokinin levels

Clinics
Joycellane Alline do Nascimento Campos RibeiroAna Heloneida de Araújo Morais

Abstract

Seeds are excellent sources of proteinase inhibitors, some of which may have satietogenic and slimming actions. We evaluated the effect of a trypsin inhibitor from Tamarindus indica L. seeds on weight gain, food consumption and cholecystokinin levels in Wistar rats. A trypsin inhibitor from Tamarindus was isolated using ammonium sulfate (30-60%) following precipitation with acetone and was further isolated with Trypsin-Sepharose affinity chromatography. Analyses were conducted to assess the in vivo digestibility, food intake, body weight evolution and cholecystokinin levels in Wistar rats. Histological analyses of organs and biochemical analyses of sera were performed. The trypsin inhibitor from Tamarindus reduced food consumption, thereby reducing weight gain. The in vivo true digestibility was not significantly different between the control and Tamarindus trypsin inhibitor-treated groups. The trypsin inhibitor from Tamarindus did not cause alterations in biochemical parameters or liver, stomach, intestine or pancreas histology. Rats treated with the trypsin inhibitor showed significantly elevated cholecystokinin levels compared with animals receiving casein or water. The results indicate that the isolated trypsin inhibitor fr...Continue Reading

Citations

Oct 17, 2015·Cancer Causes & Control : CCC·Andrew J PellattMartha L Slattery
Jan 13, 2018·Journal of Enzyme Inhibition and Medicinal Chemistry·Amanda Fernandes de MedeirosAna Heloneida de Araújo Morais
Feb 9, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Vanessa Cristina Oliveira de LimaAna Heloneida de Araújo Morais
May 30, 2017·Journal of Nutritional Science and Vitaminology·Akihiro MaetaKyoko Takahashi
Nov 26, 2019·Food Science & Nutrition·Muhammad Sajid ArshadHafiza Rehana
Oct 3, 2019·Medicine·Amanda Fernandes de MedeirosAna Heloneida de Araújo Morais
Jan 26, 2021·Journal of Enzyme Inhibition and Medicinal Chemistry·Amanda Fernandes de MedeirosAna Heloneida de Araújo Morais

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