PMID: 12759448May 22, 2003Paper

Tryptase precursors are preferentially and spontaneously released, whereas mature tryptase is retained by HMC-1 cells, Mono-Mac-6 cells, and human skin-derived mast cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
Lawrence B SchwartzYoshihiro Fukuoka

Abstract

Tryptase (alpha and beta) levels in serum are used to assess mast cell involvement in human disease. Using cultured cells, the current study examines the hypothesis that protryptase(s) are spontaneously secreted by mast cells at rest, whereas mature tryptase(s) are stored in secretory granules until their release by activated cells. HMC-1 cells have only beta-tryptase genes and the corresponding mRNA. Mono-Mac-6 cells have both alpha- and beta-tryptase genes but preferentially express alpha-tryptase. Mono-Mac-6 cells spontaneously secrete most of their tryptase, which consists of alpha-protryptase, whereas mature tryptase is retained inside these cells. HMC-1 cells also spontaneously secrete most of their tryptase, identified as beta-protryptase, and retain mature tryptase. Skin-derived mast cells retain most of their tryptase, which is mature, and spontaneously secrete protryptase(s). Total tryptase levels in plasma are detectable but no different in healthy subjects with and without the gene for alpha-tryptase, consistent with pro forms of both alpha- and beta-tryptase being spontaneously secreted. Thus, protryptase(s) are spontaneously secreted by resting mast cells, whereas mature tryptase is retained by mast cells until th...Continue Reading

References

Jul 1, 1992·The Journal of Allergy and Clinical Immunology·P W van der LindenJ K van der Zwan
May 1, 1990·Journal of Leukocyte Biology·J H ButterfieldP C Roche
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P VandersliceG H Caughey
Oct 1, 1989·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A M IraniL B Schwartz
Jan 1, 1988·Leukemia Research·J H ButterfieldG J Gleich
Mar 15, 1988·International Journal of Cancer. Journal International Du Cancer·H W Ziegler-HeitbrockG Riethmüller
Jun 25, 1987·The New England Journal of Medicine·L B SchwartzT Sullivan
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Jan 1, 1994·Methods in Enzymology·L B Schwartz
May 1, 1994·Journal of Clinical Immunology·L B SchwartzP W Van der Linden
May 1, 1994·Scandinavian Journal of Immunology·G NilssonL Hellman
Oct 1, 1993·Scandinavian Journal of Immunology·R HuangL Hellman
Feb 1, 1993·Scandinavian Journal of Immunology·T Blom, L Hellman
Feb 1, 1996·Protein Expression and Purification·K SakaiL B Schwartz
Jan 28, 1999·The Journal of Biological Chemistry·M PallaoroG H Caughey
Mar 30, 2001·The Journal of Biological Chemistry·P J WoltersG H Caughey
May 30, 2001·Leukemia Research·P ValentJ M Bennett
Jul 9, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D SotoG H Caughey
Aug 1, 2002·Leukemia & Lymphoma·W R SperrP Valent
Aug 7, 2002·Journal of Molecular Biology·Ulf MarquardtChristian Sommerhoff
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hong-Wei WangJohn E Hunt

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Citations

Jul 9, 2004·Emergency Medicine Australasia : EMA·Simon G A BrownRobert J Heddle
Nov 22, 2008·European Journal of Clinical Investigation·N M Kushnir-SukhovD D Metcalfe
May 29, 2009·Current Opinion in Allergy and Clinical Immunology·Franziska RuëffBernhard Przybilla
May 13, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Quang T LeLawrence B Schwartz
May 11, 2011·Immunotherapy·David González-de-OlanoLuis Escribano
Jul 12, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Quang T LeLawrence B Schwartz
Jan 1, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A M AbdelmotelbJ W Holloway
Jul 25, 2019·The Journal of Experimental Medicine·Quang T LeLawrence B Schwartz
Apr 8, 2006·International Archives of Allergy and Immunology·P KomerickiW Aberer
Apr 28, 2006·The FEBS Journal·Jenny Hallgren, Gunnar Pejler
Oct 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Neil N TrivediGeorge H Caughey
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wilfred W RaymondGeorge H Caughey
Jan 27, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S Dugas-BreitF Ruëff
Aug 30, 2014·Expert Review of Hematology·Peter ValentMichel Arock
Aug 20, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M FerrerL B Schwartz
Aug 23, 2008·Archives of Dermatological Research·Ilkka T HarvimaAnita Naukkarinen
Oct 12, 2011·International Archives of Allergy and Immunology·R V FengerA Gonzalez-Quintela
Jun 20, 2014·Arthritis & Rheumatology·Laurent L ReberStephen J Galli
Aug 6, 2019·Paediatric Anaesthesia·Bojana StepanovicBritta S von Ungern-Sternberg
Nov 30, 2019·Current Allergy and Asthma Reports·Paneez Khoury, Jonathan J Lyons
Jan 25, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y BerkunM Shalit
Jul 2, 2010·The New England Journal of Medicine·Anne Y LiuJoseph Loscalzo
Jun 6, 2007·Current Allergy and Asthma Reports·Susan I Hungness, Cem Akin
Dec 17, 2008·The British Journal of Dermatology·S GerdesU Mrowietz
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshihiro FukuokaLawrence B Schwartz
May 4, 2012·International Journal of Laboratory Hematology·I Alvarez-TwoseL Escribano
Mar 19, 2016·Allergy·C MayorgaUNKNOWN In vitro tests for Drug Allergy Task Force of EAACI Drug Interest Group
Dec 27, 2016·Frontiers in Cellular and Infection Microbiology·Elisabeth HodilleOana Dumitrescu
Jul 28, 2020·The Journal of Allergy and Clinical Immunology·Jonathan J LyonsPeter Korošec
Sep 3, 2019·The Journal of Allergy and Clinical Immunology·Catherine R WeilerLawrence B Schwartz
Feb 13, 2021·Medicina·Arianna GiannettiAndrea Pession
Mar 7, 2021·International Journal of Molecular Sciences·Bettina SprinzlGregor Hoermann
Mar 23, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Joana VitteMariana C Castells
Mar 23, 2021·The Journal of Allergy and Clinical Immunology·Jason GotlibCem Akin
May 2, 2021·Current Opinion in Immunology·Jonathan J Lyons, Tangsheng Yi
May 11, 2021·Current Allergy and Asthma Reports·Richard Wu, Jonathan J Lyons
May 10, 2007·Archives of Pathology & Laboratory Medicine·Mrinal M PatnaikAnimesh Pardanani
Jun 28, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jonathan J Lyons
Feb 15, 2005·Archives of Biochemistry and Biophysics·Wilfred W RaymondGeorge H Caughey
Aug 26, 2006·Immunology and Allergy Clinics of North America·Lawrence B Schwartz
May 12, 2007·Immunology and Allergy Clinics of North America·Yoshiko Ogawa, J Andrew Grant
Nov 28, 2007·International Immunopharmacology·Yoshihiro Fukuoka, Lawrence B Schwartz
Aug 24, 2021·The Journal of Allergy and Clinical Immunology·Allyson MatejaJonathan J Lyons

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