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Tryptophan 2,3-dioxygenase expression identified in human hepatocellular carcinoma cells and in intratumoral pericytes of most cancers

Cancer Immunology Research

Dec 7, 2019

Delia HoffmannBenoît J Van den Eynde

Abstract

Tryptophan catabolism is used by tumors to resist immune attack. It can be catalyzed by indoleamine 2,3-dioxygenase (IDO1) and tryptophan 2,3-dioxygenase (TDO). IDO1 is frequently expressed in tumors and has been widely studied as a potential therapeutic target to reduce resistance to c...read more

Mentioned in this Paper

Nec protein, Drosophila
Immunohistochemistry
Focal
Indoleamine-Pyrrole 2,3,-Dioxygenase
Lung Neoplasms
JM 2820
Neoplasms
Pathologic Neovascularization
Monoclonal Antibodies
Immunotherapy for Cancer
10
1
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Tryptophan 2,3-dioxygenase expression identified in human hepatocellular carcinoma cells and in intratumoral pericytes of most cancers

Cancer Immunology Research

Dec 7, 2019

Delia HoffmannBenoît J Van den Eynde

PMID: 31806639

DOI: 10.1158/2326-6066.cir-19-0040

Abstract

Tryptophan catabolism is used by tumors to resist immune attack. It can be catalyzed by indoleamine 2,3-dioxygenase (IDO1) and tryptophan 2,3-dioxygenase (TDO). IDO1 is frequently expressed in tumors and has been widely studied as a potential therapeutic target to reduce resistance to c...read more

Mentioned in this Paper

Nec protein, Drosophila
Immunohistochemistry
Focal
Indoleamine-Pyrrole 2,3,-Dioxygenase
Lung Neoplasms
JM 2820
Neoplasms
Pathologic Neovascularization
Monoclonal Antibodies
Immunotherapy for Cancer
10
1

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