Tryptophan-Assisted Synthesis Reduces Bimetallic Gold/Silver Nanoparticle Cytotoxicity and Improves Biological Activity

Nanobiomedicine
Igor ShmarakovAnna Eremenko

Abstract

Aiming to reduce the potential in vivo hepato-and nephrotoxicity of Ag/Au bimetallic nanoparticles (NPs) stabilized by sodium dodecyl sulphate (SDS), an approach involving a simultaneous reduction of silver nitrate and tetrachlorauratic acid using tryptophan (Trp) as a reducing/stabilizing agent was applied during NP synthesis. The obtained Ag/Au/Trp NPs (5-15 nm sized) were able to form stable aggregates with an average size of 370-450 nm and were potentially less toxic than Ag/Au/SDS in relation to a mouse model system based on clinical biochemical parameters and oxidative damage product estimation. Ag/Au/Trp NPs were shown to exhibit anticancer activity in relation to a Lewis lung carcinoma model. The data generated from the present study support the fact that the use of tryptophan in NP synthesis is effective in attenuating the potential hepatotoxicity and nephrotoxicity of NPs during their in vivo application.

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Citations

Feb 26, 2016·Nanoscale Research Letters·Iuliia MukhaNataliia Smirnova
Jan 28, 2020·Journal of Drug Targeting·Shaheen SultanaNasir Ali Siddiqui
May 10, 2017·Nanoscale Research Letters·Igor ShmarakovAnna Eremenko
Jul 20, 2019·Journal of Fluorescence·Mariana VoicescuDaniela C Culita

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Methods Mentioned

BETA
surface plasmon resonance

Software Mentioned

PCS
ImageJ
– Size mode
LAB
AAS

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