Tryptophan catabolism and immune activation in primary and chronic HIV infection

BMC Infectious Diseases
Marco GelpiSusanne D Nielsen

Abstract

Kynurenine/Tryptophan ratio (KTR) is increased in HIV infection, and linked to immune activation. We hypothesized that early cART initiation results in lower KTR compared to late initiation. Furthermore, we hypothesized that KTR prior to cART is a predictor of the magnitude of subsequent reduction in immune activation. Prospective study including 57 HIV-infected individuals (primary HIV infection (N = 14), early presenters (>350 CD4+ T cells/μL, N = 24), late presenters (<200 CD4+ T cells/μL, N = 19)). Kynurenine and tryptophan were analysed by liquid chromatography-tandem mass spectrometry. Total CD4+ and CD8+ T cells were determined and proportion of activated CD38 + HLA-DR+ Tcells was measured using flow cytometry at baseline and after 6 and 12 months of cART. At baseline, primary HIV infection had higher KTR than early presenters. However, similar KTR in primary HIV infection and early presenters was found after cART initiation, while late presenters had higher KTR at all time points. In primary HIV infection and early presenters, KTR was positively associated with proportion of activated cells at baseline. Furthermore, in early presenters the KTR at baseline was associated with proportion of activated cells after 6 and 12 ...Continue Reading

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Citations

Feb 14, 2020·The Journal of Antimicrobial Chemotherapy·Marie-Angélique De ScheerderLinos Vandekerckhove
Feb 13, 2019·BMC Infectious Diseases·Sukeshani SalweVainav Patel
Nov 19, 2019·Frontiers in Cellular and Infection Microbiology·Clement Gascua Adu-GyamfiMelinda Shelley Suchard
Sep 21, 2019·The Journal of Infectious Diseases·Marco GelpiUNKNOWN Copenhagen Comorbidity in HIV Infection (COCOMO) Study
Sep 12, 2020·The Journal of Infectious Diseases·Samuel R SchnittmanPeter W Hunt
Feb 27, 2021·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ninna DrivsholmMarco Gelpi

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Methods Mentioned

BETA
flow cytometry
Facs

Software Mentioned

SPSS
FACS Diva

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