PMID: 11331552May 2, 2001Paper

Tryptophan depletion and its implications for psychiatry

The British Journal of Psychiatry : the Journal of Mental Science
C BellDavid J Nutt

Abstract

Over the past 10 years the technique of tryptophan depletion has been used increasingly as a tool for studying brain serotonergic systems. To review the technique of tryptophan depletion and its current status as a tool for investigating psychiatric disorders. Systematic review of preclinical and clinical studies. Tryptophan depletion produces a marked reduction in plasma tryptophan and consequently brain serotonin (5-HT) synthesis and release. In healthy volunteers the effects of tryptophan depletion are influenced by the characteristics of the subjects and include some mood lowering, some memory impairment and an increase in aggression. In patients with depression tryptophan depletion tends to result in no worsening of depression in untreated subjects but a relapse in those who have responded to antidepressants (particularly serotonergic agents). In panic disorder the results are similar. The findings that tryptophan depletion produces a relapse of symptoms in patients with depression and panic disorder who have responded to treatment with antidepressants suggests that enhanced 5-HT function is important in maintaining response in these conditions.

References

Nov 1, 1990·Psychological Medicine·I M AndersonP J Cowen
Jan 1, 1985·Psychopharmacology·S N YoungF R Ervin
Jul 15, 1995·Biological Psychiatry·A W GoddardL H Price
Sep 1, 1996·Biological Psychiatry·E SmeraldiE A Moja
Mar 29, 1997·Lancet·K A SmithP J Cowen
Apr 1, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M LeytonC Benkelfat
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·S NishizawaM Diksic
Aug 1, 1997·The American Journal of Psychiatry·A NeumeisterS Kasper
Dec 31, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·L H PriceG R Heninger
Jan 16, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·U VoderholzerF Hohagen
Jan 1, 1997·Journal of Psychopharmacology·J G ReillyA H Young
Mar 12, 1998·Biological Psychiatry·F CassidyB J Carroll
Jun 3, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·L L CarpenterC J McDougle
Nov 26, 1998·The British Journal of Psychiatry : the Journal of Mental Science·C J Bell, D J Nutt
Feb 20, 1999·Archives of General Psychiatry·K A SmithP J Cowen
Aug 25, 1999·Biological Psychiatry·F A MorenoP L Delgado
Oct 16, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·D J NuttS Argyropoulos
Jan 14, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M LeytonC Benkelfat
Feb 9, 2000·Biological Psychiatry·W H KayeT E Weltzin
Mar 4, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J M BjorkA C Swann
Mar 18, 2000·Advances in Experimental Medicine and Biology·C Huwig-PoppeF Hohagen
Mar 30, 2000·The American Journal of Psychiatry·R J PorterJ T O'Brien
Feb 7, 2001·The British Journal of Psychiatry : the Journal of Mental Science·H E MillerI M Anderson

❮ Previous
Next ❯

Citations

Oct 31, 2002·Human Psychopharmacology·Ben J HarrisonPradeep J Nathan
Apr 26, 2007·Psychopharmacology·John BrownJeff Ward
Nov 30, 2012·European Archives of Psychiatry and Clinical Neuroscience·Markus J SchwarzHarald Hampel
May 12, 2005·Neuroscience and Biobehavioral Reviews·Adrian J DunnRenaud de Beaurepaire
Jan 25, 2003·Pharmacology, Biochemistry, and Behavior·Mary PeruginiVerner Knott
Oct 29, 2002·Brain, Behavior, and Immunity·Bernhard WidnerDietmar Fuchs
Feb 3, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jonathan P RoiserBarbara J Sahakian
Sep 1, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eduard Maron, Jakov Shlik
Dec 8, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kirsty E ScholesPradeep J Nathan
Mar 10, 2004·The British Journal of Nutrition·Michiel A van NieuwenhovenRobert-Jan M Brummer
Apr 26, 2012·Journal of Chromatographic Science·Najma SultanaAgha Zeeshan Mirza
Jul 25, 2009·Social Cognitive and Affective Neuroscience·Lihong WangScott A Huettel
Jul 14, 2005·Journal of Clinical Psychopharmacology·Arif KhanWalter A Brown
Mar 7, 2009·Menopause : the Journal of the North American Menopause Society·Janet S CarpenterTodd C Skaar
Apr 1, 2004·Acta Neuropsychiatrica·A C PyleD J Nutt
Nov 14, 2012·Psychotherapy and Psychosomatics·Louisa G SylviaAndrew A Nierenberg
Sep 15, 2004·Nutrition Journal·Reeta HakkarainenJouko Lönnqvist
Oct 3, 2009·Environmental Health : a Global Access Science Source·Xin QiWenbiao Hu
Feb 6, 2008·PLoS Computational Biology·Peter Dayan, Quentin J M Huys
Jul 26, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Maximilian LedochowskiDietmar Fuchs
Dec 5, 2013·Neuroscience and Biobehavioral Reviews·Ian MaharJosé N Nobrega
Sep 26, 2013·Journal of Neural Transmission·Cristina L SánchezFlorian D Zepf
Aug 12, 2014·Pathologie-biologie·M O MelanconI J Dionne
May 22, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Yu ZhaoYong-Yu Zhang
Nov 3, 2011·The British Journal of Psychiatry : the Journal of Mental Science·David Nutt
May 17, 2006·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Edward C Suarez, K Ranga R Krishnan
Jan 13, 2006·International Review of Psychiatry·Michele L Pucak, Adam I Kaplin
Sep 30, 2010·Expert Opinion on Therapeutic Targets·Nina K Popova, Alexander V Kulikov
Jan 1, 2004·International Journal of Psychiatry in Clinical Practice·David Nutt
Mar 11, 2011·Revista da Associação Médica Brasileira·Fernanda de Matos FeijóCíntia Reis
May 10, 2005·The Journal of Physiology·Zhong-wei Zhang, Dany Arsenault
Sep 10, 2003·Depression and Anxiety·Reeta HakkarainenJouko Lönnqvist
May 11, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jessica EcclesRichard Whale

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

© 2021 Meta ULC. All rights reserved