Tryptophan hydroxylase-2 controls brain serotonin synthesis

Science
Xiaodong ZhangMarc G Caron

Abstract

Dysregulation of brain serotonin contributes to many psychiatric disorders. Tryptophan hydroxylase-2 (Tph2), rather than Tph1, is preferentially expressed in the brain. We report a functional (C1473G) single-nucleotide polymorphism in mouse Tph2 that results in the substitution of Pro447 with Arg447 and leads to decreased serotonin levels in PC12 cells. Moreover, in BALB/cJ and DBA/2 mice that are homozygous for the 1473G allele, brain serotonin tissue content and synthesis are reduced in comparison to C57Bl/6 and 129X1/SvJ mice that are homozygous for the 1473C allele. Our data provide direct evidence for a fundamental role of Tph2 in brain serotonin synthesis.

References

Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·L A Greene, A S Tischler
Jan 11, 2001·Pharmacology & Therapeutics·S J Bonasera, L H Tecott
Aug 28, 2001·Nucleic Acids Research·S YeI N Day
Jan 4, 2003·Science·Diego J WaltherMichael Bader

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Citations

May 24, 2007·Molecular Neurobiology·Kazuhiro Nakamura, Hiroyuki Hasegawa
Dec 27, 2005·Cellular and Molecular Life Sciences : CMLS·X ZhangM G Caron
Dec 7, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Raul R Gainetdinov
Nov 26, 2010·Psychopharmacology·Gregory V Carr, Irwin Lucki
Dec 25, 2010·Psychopharmacology·Jianwei JiaoStephanie C Dulawa
Apr 25, 2012·Brain Structure & Function·María Eugenia Cornide-PetronioAntón Barreiro-Iglesias
Jun 10, 2009·Human Genetics·Ian W Craig, Kelly E Halton
Oct 27, 2006·Journal of Neural Transmission·S AnttilaT Lehtimäki
Jul 31, 2008·Journal of Neural Transmission·Lise GutknechtKlaus-Peter Lesch
May 13, 2009·Journal of Neural Transmission·Martin MarziniakRainald Mössner
Jun 10, 2006·Cellular and Molecular Neurobiology·Nashat AbumariaGabriele Flügge
Jan 17, 2008·Cellular and Molecular Neurobiology·Nashat AbumariaGabriele Flügge
Apr 5, 2005·Brain Research·Maura BoldriniVictoria Arango
Apr 29, 2005·Brain Research. Molecular Brain Research·Rachel L SanchezCynthia L Bethea
Jan 22, 2013·ACS Chemical Neuroscience·William B SiesserRaul R Gainetdinov
Jan 6, 2010·Molecular Psychiatry·E MaronJ Shlik
Sep 22, 2010·Molecular Psychiatry·X ZhangM G Caron
Apr 12, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stefan M BergerDusan Bartsch
May 24, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vanda FariaTomas Furmark
Sep 3, 2005·Nature Reviews. Drug Discovery·John F Cryan, Andrew Holmes
Jun 9, 2005·Molecular Psychiatry·K SheehanZ Hawi
Sep 1, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eduard Maron, Jakov Shlik
Sep 30, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Helene Bach-MizrachiVictoria Arango
Mar 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James J CrowleyIrwin Lucki
Aug 15, 2013·Translational Psychiatry·B D SachsM G Caron
Jan 4, 2008·The New England Journal of Medicine·R H Belmaker, Galila Agam
Jan 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jean-Martin BeaulieuMarc G Caron
Jun 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Natalia AleninaMichael Bader
Apr 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xin-jie TanJan-Åke Gustafsson
Aug 2, 2012·Proceedings of the National Academy of Sciences of the United States of America·Huei-Hsuan ChengKenneth K Wu

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