PMID: 3747417Jul 1, 1986Paper

Tryptophan metabolism in liver diseases: a pharmacokinetic and enzymatic study

Klinische Wochenschrift
M RössleW Gerok

Abstract

Tryptophan is considered to be one of the agents involved in the pathogenesis of hepatic encephalopathy. In our study, we evaluated tryptophan metabolism in liver disease. A bolus of 1.5 g of L-tryptophan was administered intravenously to 14 patients with noncirrhotic liver disease, 40 patients with liver cirrhosis, and 8 healthy volunteers. As pharmacokinetic parameters, the half life, clearance, and volume of distribution of free and total tryptophan were determined using a biexponential formula. In addition, the activity of liver tryptophan pyrrolase, the key enzyme of tryptophan metabolism, was measured in liver biopsy specimens of 15 patients with noncirrhotic liver disease, 8 patients with cirrhosis of the liver, and 4 patients with histologically normal livers. Healthy subjects and patients with noncirrhotic liver disease both showed similar results in measured and calculated data. In contrast, patients with cirrhosis revealed significant alterations of the pharmacokinetic parameters of free and total tryptophan: the half-life was increased by 195% and 176%, the clearance was decreased by 73% and 34%, respectively, and the activity of tryptophan pyrrolase was decreased by 22%. The tryptophan transfer in cirrhosis amounte...Continue Reading

References

Jan 1, 1977·Clinical Pharmacokinetics·T F Blaschke
Aug 1, 1976·Journal of Neurochemistry·M G CummingsJ E Fischer
Apr 1, 1976·Metabolism: Clinical and Experimental·J H JamesJ E Fischer
Jun 1, 1971·The American Journal of Clinical Nutrition·J E Leklem
Jul 1, 1973·Journal of Neurochemistry·G CurzonR Williams
Mar 23, 1974·British Medical Journal·A J KnellG Curzon
Feb 1, 1982·Digestive Diseases and Sciences·J E Fischer
Feb 28, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·K Yoshida, C Hirayama
Jun 1, 1982·European Journal of Clinical Investigation·H VilstrupS E Damgård

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Citations

Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·E HolmE Grips
Jun 1, 2002·Nutrition Research Reviews·Abdulla A-B Badawy
Sep 27, 2020·The Journal of Pharmacy and Pharmacology·Zhipeng WangXiaohui Chen
Sep 7, 2019·International Journal of Tryptophan Research : IJTR·Abdulla A-B Badawy, Gilles Guillemin

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