journal cover

Tryptophan trimers and tetramers inhibit dengue and Zika virus replication by interfering with viral attachment processes

Antimicrobial Agents and Chemotherapy

Jan 15, 2020

Antonios FikatasDominique Schols

Abstract

Here, we report a class of tryptophan trimers and tetramers that inhibit (at low micromolar range) dengue and Zika virus infection in vitro These compounds (AL family) have three or four peripheral tryptophan moieties directly linked to a central scaffold through their amino groups, thu...read more

Mentioned in this Paper

Administration of Prophylactic Medication
Viral Envelope Proteins
Primary amyloidosis
Laboratory
Evaluation
Influenza A virus
Zika virus (organism)
Flavivirus
Dengue virus, type 2
Study
1
Paper Details
References
  • References50
  • Citations
12345
  • References50
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Similar Papers Found In These Feeds

Influenza Virus

Influenza viruses comprise a major class of human respiratory pathogens, responsible for causing morbidity and mortality worldwide. Discover the latest research on Influenza Viruses here.

Ebola Virus

Ebola Virus causes ebola virus disease, and is one of the deadliest pathogens known to man, with a mortality rate between 25-90% depending on the species and outbreak of ebola. Discover the latest research on Ebola Virus.

Influenza

Influenza, commonly known as the flu, is an infectious disease caused by an influenza virus.Symptoms can be mild to severe. The most common symptoms include: high fever, runny nose, sore throat, muscle pains, headache, coughing, sneezing, and feeling tired. Discover the latest research on influenza here.

Immunoglobulin Light-chain Amyloidosis

Immunoglobulin Light-chain Amyloidosis is a disease characterized by excessive production of misfolded immunoglobulin light chains by plasma cells and leads to amyloid deposition. Discover the latest research on Immunoglobulin Light-chain Amyloidosis here.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Vitamin K Carboxylase & Antibiotics

Vitamin K-dependent carboxylases generate gamma-carboxyglutamic acids with malonate moieties by modifying glutamate residues in vitamin K-dependent proteins. This feed focuses on cellular mechanisms regulated by vitamin K-dependent carboxylases.

HIV-1 Reverse Transcriptase

HIV-1 reverse transcriptase is among the earliest HIV proteins identified and is involved in viral replication. More than half of investigational long-acting antivirals target hiv-1 reverse transcriptase and/or integrase (hiv-1 in). Discover the latest research here.

Viral Packing & Assembly

Viral capsids typically self-assemble around the viral genome in the host cytoplasm. This feed focuses on mechanisms that play a role in packaging viral DNA into the capsid.

Dengue Virus

Dengue Virus, a mosquito transmitted pathogen, is the causative agent of dengue fever, the most important arboviral disease of humans, which affects an estimated 50-100 million people annually. Discover the latest research here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

The Journal of Infectious Diseases

Zika Virus-Induced Antibody Response Enhances Dengue Virus Serotype 2 Replication In Vitro

The Journal of Infectious DiseasesAugust 16, 2016
Anna B Kawiecki, Rebecca C Christofferson
Nature

Effects of dengue immunity on Zika virus infection

NatureMarch 27, 2019
Stephen S Whitehead, Theodore C Pierson
© 2020 Meta ULC. All rights reserved

Tryptophan trimers and tetramers inhibit dengue and Zika virus replication by interfering with viral attachment processes

Antimicrobial Agents and Chemotherapy

Jan 15, 2020

Antonios FikatasDominique Schols

PMID: 31932383

DOI: 10.1128/aac.02130-19

Abstract

Here, we report a class of tryptophan trimers and tetramers that inhibit (at low micromolar range) dengue and Zika virus infection in vitro These compounds (AL family) have three or four peripheral tryptophan moieties directly linked to a central scaffold through their amino groups, thu...read more

Mentioned in this Paper

Administration of Prophylactic Medication
Viral Envelope Proteins
Primary amyloidosis
Laboratory
Evaluation
Influenza A virus
Zika virus (organism)
Flavivirus
Dengue virus, type 2
Study
1

Similar Papers Found In These Feeds

Influenza Virus

Influenza viruses comprise a major class of human respiratory pathogens, responsible for causing morbidity and mortality worldwide. Discover the latest research on Influenza Viruses here.

Related Papers

The Journal of Infectious Diseases

Zika Virus-Induced Antibody Response Enhances Dengue Virus Serotype 2 Replication In Vitro

The Journal of Infectious DiseasesAugust 16, 2016
Anna B Kawiecki, Rebecca C Christofferson
Nature

Effects of dengue immunity on Zika virus infection

NatureMarch 27, 2019
Stephen S Whitehead, Theodore C Pierson
Paper Details
References
  • References50
  • Citations
12345
  • References50
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
/papers/tryptophan-trimers-and-tetramers-inhibit-dengue/31932383